Summary
This is the summary of UniProt entry HDAC3_HUMAN (O15379).
| Description: | Histone deacetylase 3 EC=3.5.1.98 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 428 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
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| Source | Domain | Start | End |
|---|---|---|---|
| Pfam | Hist_deacetyl | 22 | 314 |
| disorder | n/a | 349 | 350 |
| disorder | n/a | 386 | 428 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O15379. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP
50 51
YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL
100 101
FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI
150 151
VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
200 201
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDFYQPT
250 251
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV
300 301
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN
350 351
SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP
400 401
EENYSRPEAP NEFYDGDHDN DKESDVEI
428
Show the unformatted sequence. |
| Checksums: |
CRC64:94485C1EBDCF5AD0
MD5:de823732d2e756f3935bd7a5d19bdba8
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Hist_deacetyl | 22 - 314 | 4A69 | A | 22 - 314 | NGL View in InterPro |
| B | 22 - 314 | NGL View in InterPro |
The parts of the structure corresponding to the Pfam family are highlighted in yellow.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
