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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: HDAC3_HUMAN (O15379)

Summary

This is the summary of UniProt entry HDAC3_HUMAN (O15379).

Description: Histone deacetylase 3 EC=3.5.1.98
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 428 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Hist_deacetyl 22 314
disorder n/a 349 350
disorder n/a 386 428

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O15379. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP
50
51
YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL
100
101
FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI
150
151
VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
200
201
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDFYQPT
250
251
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV
300
301
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN
350
351
SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP
400
401
EENYSRPEAP NEFYDGDHDN DKESDVEI                        
428
 

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Checksums:
CRC64:94485C1EBDCF5AD0
MD5:de823732d2e756f3935bd7a5d19bdba8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Hist_deacetyl 22 - 314 4A69 A 22 - 314 NGL View in InterPro
B 22 - 314 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.