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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MCES_HUMAN (O43148)

Summary

This is the summary of UniProt entry MCES_HUMAN (O43148).

Description: mRNA cap guanine-N7 methyltransferase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 476 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 50
disorder n/a 52 55
disorder n/a 60 149
Pfam Pox_MCEL 136 475
disorder n/a 152 157
low_complexity n/a 201 217

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43148. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MANSAKAEEY EKMSLEQAKA SVNSETESSF NINENTTASG TGLSEKTSVC
50
51
RQVDIARKRK EFEDDLVKES SSCGKDTPSK KRKLDPEIVP EEKDCGDAEG
100
101
NSKKRKRETE DVPKDKSSTG DGTQNKRKIA LEDVPEKQKN LEEGHSSTVA
150
151
AHYNELQEVG LEKRSQSRIF YLRNFNNWMK SVLIGEFLEK VRQKKKRDIT
200
201
VLDLGCGKGG DLLKWKKGRI NKLVCTDIAD VSVKQCQQRY EDMKNRRDSE
250
251
YIFSAEFITA DSSKELLIDK FRDPQMCFDI CSCQFVCHYS FESYEQADMM
300
301
LRNACERLSP GGYFIGTTPN SFELIRRLEA SETESFGNEI YTVKFQKKGD
350
351
YPLFGCKYDF NLEGVVDVPE FLVYFPLLNE MAKKYNMKLV YKKTFLEFYE
400
401
EKIKNNENKM LLKRMQALEP YPANESSKLV SEKVDDYEHA AKYMKNSQVR
450
451
LPLGTLSKSE WEATSIYLVF AFEKQQ                          
476
 

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Checksums:
CRC64:EC919BC41BD5E2B3
MD5:6e07fd6779c43aa49802d4f9d9ae3642

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pox_MCEL 167 - 475 5E8J A 167 - 475 Jmol OpenAstexViewer
B 167 - 475 Jmol OpenAstexViewer
5E9J A 167 - 439 Jmol OpenAstexViewer
B 167 - 439 Jmol OpenAstexViewer
5E9W A 167 - 475 Jmol OpenAstexViewer
C 167 - 475 Jmol OpenAstexViewer
D 167 - 475 Jmol OpenAstexViewer
168 - 475 3BGV A 4 - 311 Jmol OpenAstexViewer
3EPP B 5 - 312 Jmol OpenAstexViewer
5E9W B 168 - 475 Jmol OpenAstexViewer
169 - 475 3BGV B 5 - 311 Jmol OpenAstexViewer
C 5 - 311 Jmol OpenAstexViewer
D 5 - 311 Jmol OpenAstexViewer
3EPP A 6 - 312 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.