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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SERA_HUMAN (O43175)

Summary

This is the summary of UniProt entry SERA_HUMAN (O43175).

Description: D-3-phosphoglycerate dehydrogenase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 533 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam 2-Hacid_dh 9 317
Pfam 2-Hacid_dh_C 111 285
low_complexity n/a 148 158
Pfam PGDH_inter 328 425
disorder n/a 408 409
low_complexity n/a 454 467

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43175. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG
50
51
LIVRSATKVT ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN
100
101
GNSLSAAELT CGMIMCLARQ IPQATASMKD GKWERKKFMG TELNGKTLGI
150
151
LGLGRIGREV ATRMQSFGMK TIGYDPIISP EVSASFGVQQ LPLEEIWPLC
200
201
DFITVHTPLL PSTTGLLNDN TFAQCKKGVR VVNCARGGIV DEGALLRALQ
250
251
SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA
300
301
VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEALG TLMRAWAGSP
350
351
KGTIQVITQG TSLKNAGNCL SPAVIVGLLK EASKQADVNL VNAKLLVKEA
400
401
GLNVTTSHSP AAPGEQGFGE CLLAVALAGA PYQAVGLVQG TTPVLQGLNG
450
451
AVFRPEVPLR RDLPLLLFRT QTSDPAMLPT MIGLLAEAGV RLLSYQTSLV
500
501
SDGETWHVMG ISSLLPSLEA WKQHVTEAFQ FHF                  
533
 

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Checksums:
CRC64:C58EB72275C45B35
MD5:76e06f0382407475a724b89fd1eb77af

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
2-Hacid_dh 100 - 294 5N53 A 100 - 294 Show 3D Structure View in InterPro
B 100 - 294 Show 3D Structure View in InterPro
5NZO A 100 - 294 Show 3D Structure View in InterPro
B 100 - 294 Show 3D Structure View in InterPro
5NZP A 100 - 294 Show 3D Structure View in InterPro
B 100 - 294 Show 3D Structure View in InterPro
5NZQ A 100 - 294 Show 3D Structure View in InterPro
B 100 - 294 Show 3D Structure View in InterPro
5OFM A 100 - 294 Show 3D Structure View in InterPro
B 100 - 294 Show 3D Structure View in InterPro
5OFV A 100 - 294 Show 3D Structure View in InterPro
B 100 - 294 Show 3D Structure View in InterPro
5OFW A 100 - 294 Show 3D Structure View in InterPro
B 100 - 294 Show 3D Structure View in InterPro
100 - 304 6RJ6 A 99 - 303 Show 3D Structure View in InterPro
9 - 302 7CVP B 9 - 302 Show 3D Structure View in InterPro
9 - 303 6CWA B 8 - 302 Show 3D Structure View in InterPro
6RJ3 A 8 - 302 Show 3D Structure View in InterPro
9 - 305 6CWA A 8 - 304 Show 3D Structure View in InterPro
7CVP A 9 - 305 Show 3D Structure View in InterPro
9 - 306 5N6C A 9 - 306 Show 3D Structure View in InterPro
B 9 - 306 Show 3D Structure View in InterPro
6PLF B 9 - 306 Show 3D Structure View in InterPro
6RJ5 A 8 - 305 Show 3D Structure View in InterPro
9 - 307 2G76 A 8 - 306 Show 3D Structure View in InterPro
B 8 - 306 Show 3D Structure View in InterPro
6PLG F 9 - 307 Show 3D Structure View in InterPro
G 9 - 307 Show 3D Structure View in InterPro
6RIH A 8 - 306 Show 3D Structure View in InterPro
B 8 - 306 Show 3D Structure View in InterPro
6RJ2 A 8 - 306 Show 3D Structure View in InterPro
B 8 - 306 Show 3D Structure View in InterPro
6RJ3 B 8 - 306 Show 3D Structure View in InterPro
6RJ5 B 8 - 306 Show 3D Structure View in InterPro
9 - 308 6PLG A 9 - 308 Show 3D Structure View in InterPro
B 9 - 308 Show 3D Structure View in InterPro
C 9 - 308 Show 3D Structure View in InterPro
D 9 - 308 Show 3D Structure View in InterPro
E 9 - 308 Show 3D Structure View in InterPro
H 9 - 308 Show 3D Structure View in InterPro
9 - 309 6PLF A 9 - 309 Show 3D Structure View in InterPro
98 - 307 6RJ6 B 97 - 306 Show 3D Structure View in InterPro
2-Hacid_dh_C 111 - 285 2G76 A 110 - 284 Show 3D Structure View in InterPro
B 110 - 284 Show 3D Structure View in InterPro
5N53 A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
5N6C A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
5NZO A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
5NZP A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
5NZQ A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
5OFM A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
5OFV A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
5OFW A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
6CWA A 110 - 284 Show 3D Structure View in InterPro
B 110 - 284 Show 3D Structure View in InterPro
6PLF A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
6PLG A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
C 111 - 285 Show 3D Structure View in InterPro
D 111 - 285 Show 3D Structure View in InterPro
E 111 - 285 Show 3D Structure View in InterPro
F 111 - 285 Show 3D Structure View in InterPro
G 111 - 285 Show 3D Structure View in InterPro
H 111 - 285 Show 3D Structure View in InterPro
6RIH A 110 - 284 Show 3D Structure View in InterPro
B 110 - 284 Show 3D Structure View in InterPro
6RJ2 A 110 - 284 Show 3D Structure View in InterPro
B 110 - 284 Show 3D Structure View in InterPro
6RJ3 A 110 - 284 Show 3D Structure View in InterPro
B 110 - 284 Show 3D Structure View in InterPro
6RJ5 A 110 - 284 Show 3D Structure View in InterPro
B 110 - 284 Show 3D Structure View in InterPro
6RJ6 A 110 - 284 Show 3D Structure View in InterPro
B 110 - 284 Show 3D Structure View in InterPro
7CVP A 111 - 285 Show 3D Structure View in InterPro
B 111 - 285 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;