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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PHF1_HUMAN (O43189)

Summary

This is the summary of UniProt entry PHF1_HUMAN (O43189).

Description: PHD finger protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 567 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 3
disorder n/a 12 20
disorder n/a 22 29
Pfam Tudor_2 34 69
Pfam PHD 89 142
disorder n/a 301 305
disorder n/a 333 442
low_complexity n/a 362 378
low_complexity n/a 414 432
disorder n/a 444 524
low_complexity n/a 455 469
low_complexity n/a 487 522
low_complexity n/a 523 533
disorder n/a 528 537
Pfam Mtf2_C 530 565
disorder n/a 540 549

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43189. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT
50
51
IKKVDSAREV CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP
100
101
GNRLVSCEKC RHAYHQDCHV PRAPAPGEGE GTSWVCRQCV FAIATKRGGA
150
151
LKKGPYARAM LGMKLSLPYG LKGLDWDAGH LSNRQQSYCY CGGPGEWNLK
200
201
MLQCRSCLQW FHEACTQCLS KPLLYGDRFY EFECCVCRGG PEKVRRLQLR
250
251
WVDVAHLVLY HLSVCCKKKY FDFDREILPF TSENWDSLLL GELSDTPKGE
300
301
RSSRLLSALN SHKDRFISGR EIKKRKCLFG LHARMPPPVE PPTGDGALTS
350
351
FPSGQGPGGG VSRPLGKRRR PEPEPLRRRQ KGKVEELGPP SAVRNQPEPQ
400
401
EQRERAHLQR ALQASVSPPS PSPNQSYQGS SGYNFRPTDA RCLPSSPIRM
450
451
FASFHPSAST AGTSGDSGPP DRSPLELHIG FPTDIPKSAP HSMTASSSSV
500
501
SSPSPGLPRR SAPPSPLCRS LSPGTGGGVR GGVGYLSRGD PVRVLARRVR
550
551
PDGSVQYLVE WGGGGIF                                    
567
 

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Checksums:
CRC64:E81BA9475565957C
MD5:0f837324fd734a27e6a1f91d57e2b6e3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PHD 89 - 142 5XFN A 89 - 142 Jmol OpenAstexViewer
5XFO A 89 - 142 Jmol OpenAstexViewer
5XFP A 89 - 142 Jmol OpenAstexViewer
B 89 - 142 Jmol OpenAstexViewer
E 89 - 142 Jmol OpenAstexViewer
Tudor_2 34 - 69 2E5P A 13 - 48 Jmol OpenAstexViewer
2M0O A 34 - 69 Jmol OpenAstexViewer
4HCZ A 34 - 69 Jmol OpenAstexViewer
B 34 - 69 Jmol OpenAstexViewer
5XFN A 34 - 69 Jmol OpenAstexViewer
5XFO A 34 - 69 Jmol OpenAstexViewer
5XFP A 34 - 69 Jmol OpenAstexViewer
B 34 - 69 Jmol OpenAstexViewer
E 34 - 69 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.