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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DAPK3_HUMAN (O43293)

Summary

This is the summary of UniProt entry DAPK3_HUMAN (O43293).

Description: Death-associated protein kinase 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 454 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Pkinase 13 275
low_complexity n/a 47 64
disorder n/a 285 296
disorder n/a 306 310
coiled_coil n/a 325 345
low_complexity n/a 330 337
coiled_coil n/a 378 398
coiled_coil n/a 406 444

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43293. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSTFRQEDVE DHYEMGEELG SGQFAIVRKC RQKGTGKEYA AKFIKKRRLS
50
51
SSRRGVSREE IEREVNILRE IRHPNIITLH DIFENKTDVV LILELVSGGE
100
101
LFDFLAEKES LTEDEATQFL KQILDGVHYL HSKRIAHFDL KPENIMLLDK
150
151
NVPNPRIKLI DFGIAHKIEA GNEFKNIFGT PEFVAPEIVN YEPLGLEADM
200
201
WSIGVITYIL LSGASPFLGE TKQETLTNIS AVNYDFDEEY FSNTSELAKD
250
251
FIRRLLVKDP KRRMTIAQSL EHSWIKAIRR RNVRGEDSGR KPERRRLKTT
300
301
RLKEYTIKSH SSLPPNNSYA DFERFSKVLE EAAAAEEGLR ELQRSRRLCH
350
351
EDVEALAAIY EEKEAWYREE SDSLGQDLRR LRQELLKTEA LKRQAQEEAK
400
401
GALLGTSGLK RRFSRLENRY EALAKQVASE MRFVQDLVRA LEQEKLQGVE
450
451
CGLR                                                  
454
 

Show the unformatted sequence.

Checksums:
CRC64:56773008A6A61CF0
MD5:c6dd47aaa3c538d2e544de17a6cc3b70

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 13 - 275 1YRP A 13 - 275 Show 3D Structure View in InterPro
B 13 - 275 Show 3D Structure View in InterPro
2J90 A 13 - 275 Show 3D Structure View in InterPro
B 13 - 275 Show 3D Structure View in InterPro
3BHY A 13 - 275 Show 3D Structure View in InterPro
3BQR A 13 - 275 Show 3D Structure View in InterPro
5A6N A 13 - 275 Show 3D Structure View in InterPro
B 13 - 275 Show 3D Structure View in InterPro
5A6O A 13 - 275 Show 3D Structure View in InterPro
B 13 - 275 Show 3D Structure View in InterPro
5VJA A 13 - 275 Show 3D Structure View in InterPro
B 13 - 275 Show 3D Structure View in InterPro
C 13 - 275 Show 3D Structure View in InterPro
D 13 - 275 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;