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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HXA2_HUMAN (O43364)

Summary

This is the summary of UniProt entry HXA2_HUMAN (O43364).

Description: Homeobox protein Hox-A2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 376 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 33 36
low_complexity n/a 34 48
disorder n/a 39 40
disorder n/a 42 98
disorder n/a 100 102
low_complexity n/a 101 125
disorder n/a 108 109
disorder n/a 113 114
disorder n/a 127 150
Pfam Homeodomain 144 200
disorder n/a 191 192
disorder n/a 198 231
low_complexity n/a 216 234
disorder n/a 251 286
disorder n/a 288 293
disorder n/a 298 305
disorder n/a 307 316
disorder n/a 320 321
disorder n/a 345 349
low_complexity n/a 359 368

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43364. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP
50
51
PFEQTIPSLN PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE
100
101
KKAAKKTALL PAAAAAATAA ATGPACLSHK ESLEIADGSG GGSRRLRTAY
150
151
TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR
200
201
QTQCKENQNS EGKCKSLEDS EKVEEDEEEK TLFEQALSVS GALLEREGYT
250
251
FQQNALSQQQ APNGHNGDSQ SFPVSPLTSN EKNLKHFQHQ SPTVPNCLST
300
301
MGQNCGAGLN NDSPEALEVP SLQDFSVFST DSCLQLSDAV SPSLPGSLDS
350
351
PVDISADSLD FFTDTLTTID LQHLNY                          
376
 

Show the unformatted sequence.

Checksums:
CRC64:78EB388FE1EEAD72
MD5:e7545a395ea77225200d7266932b9fd4

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;