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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SUV91_HUMAN (O43463)

Summary

This is the summary of UniProt entry SUV91_HUMAN (O43463).

Description: Histone-lysine N-methyltransferase SUV39H1 EC=2.1.1.43
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 412 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Chromo 43 92
low_complexity n/a 92 102
coiled_coil n/a 114 141
Pfam Pre-SET 136 235
Pfam SET 255 366

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43463. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD
50
51
YKKIREQEYY LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR
100
101
HHRSKTPRHL DPSLANYLVQ KAKQRRALRR WEQELNAKRS HLGRITVENE
150
151
VDLDGPPRAF VYINEYRVGE GITLNQVAVG CECQDCLWAP TGGCCPGASL
200
201
HKFAYNDQGQ VRLRAGLPIY ECNSRCRCGY DCPNRVVQKG IRYDLCIFRT
250
251
DDGRGWGVRT LEKIRKNSFV MEYVGEIITS EEAERRGQIY DRQGATYLFD
300
301
LDYVEDVYTV DAAYYGNISH FVNHSCDPNL QVYNVFIDNL DERLPRIAFF
350
351
ATRTIRAGEE LTFDYNMQVD PVDMESTRMD SNFGLAGLPG SPKKRVRIEC
400
401
KCGTESCRKY LF                                         
412
 

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Checksums:
CRC64:AF6F959AD20C6C76
MD5:7596a2d31c330d06d7546a7c5f7f0792

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Chromo 44 - 92 3MTS A 44 - 92 Jmol OpenAstexViewer
B 44 - 92 Jmol OpenAstexViewer
C 44 - 92 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.