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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HTRA2_HUMAN (O43464)

Summary

This is the summary of UniProt entry HTRA2_HUMAN (O43464).

Description: Serine protease HTRA2, mitochondrial EC=3.4.21.108
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 458 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 2
disorder n/a 35 40
disorder n/a 42 44
disorder n/a 69 99
low_complexity n/a 103 129
transmembrane n/a 105 124
low_complexity n/a 127 142
disorder n/a 132 138
Pfam Trypsin_2 182 320
low_complexity n/a 198 208
disorder n/a 244 245
disorder n/a 344 350
disorder n/a 352 353
Pfam PDZ_6 392 443

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43464. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV
50
51
TYGTPSLWAR LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG
100
101
TRSRAWLAVA LGAGGAVLLL LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI
150
151
ADVVEKTAPA VVYIEILDRH PFLGREVPIS NGSGFVVAAD GLIVTNAHVV
200
201
ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD
250
251
VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
300
301
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS
350
351
SSGISGSQRR YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS
400
401
PAHRAGLRPG DVILAIGEQM VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL
450
451
YVTPEVTE                                              
458
 

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Checksums:
CRC64:CEA955A7D0DD8C0D
MD5:ece138e7d403cd2f1597c723a72f1676

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PDZ_6 392 - 441 5M3O A 392 - 441 Jmol OpenAstexViewer
392 - 442 5TNY A 392 - 442 Jmol OpenAstexViewer
392 - 443 1LCY A 259 - 310 Jmol OpenAstexViewer
2PZD A 392 - 443 Jmol OpenAstexViewer
B 392 - 443 Jmol OpenAstexViewer
5FHT A 259 - 310 Jmol OpenAstexViewer
5M3N A 392 - 443 Jmol OpenAstexViewer
5TNZ A 392 - 443 Jmol OpenAstexViewer
5TO0 A 392 - 443 Jmol OpenAstexViewer
5TO1 A 392 - 443 Jmol OpenAstexViewer
Trypsin_2 182 - 320 1LCY A 49 - 187 Jmol OpenAstexViewer
5FHT A 49 - 187 Jmol OpenAstexViewer
5M3N A 182 - 320 Jmol OpenAstexViewer
5M3O A 182 - 320 Jmol OpenAstexViewer
5TNY A 182 - 320 Jmol OpenAstexViewer
5TNZ A 182 - 320 Jmol OpenAstexViewer
5TO0 A 182 - 320 Jmol OpenAstexViewer
5TO1 A 182 - 320 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.