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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CAC1G_HUMAN (O43497)

Summary

This is the summary of UniProt entry CAC1G_HUMAN (O43497).

Description: Voltage-dependent T-type calcium channel subunit alpha-1G
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2377 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 45
low_complexity n/a 1 11
low_complexity n/a 25 36
Pfam Ion_trans 80 406
transmembrane n/a 82 101
low_complexity n/a 118 128
transmembrane n/a 122 142
low_complexity n/a 199 210
transmembrane n/a 214 237
low_complexity n/a 218 229
low_complexity n/a 289 298
transmembrane n/a 342 363
low_complexity n/a 368 379
transmembrane n/a 369 394
disorder n/a 469 470
disorder n/a 473 551
low_complexity n/a 478 506
disorder n/a 553 556
disorder n/a 567 636
disorder n/a 680 684
disorder n/a 686 716
Pfam Ion_trans 742 975
transmembrane n/a 744 762
transmembrane n/a 774 795
transmembrane n/a 807 823
transmembrane n/a 865 884
low_complexity n/a 869 883
transmembrane n/a 905 921
transmembrane n/a 941 964
disorder n/a 991 994
disorder n/a 996 1008
disorder n/a 1036 1038
disorder n/a 1045 1228
low_complexity n/a 1084 1111
low_complexity n/a 1132 1148
low_complexity n/a 1206 1225
Pfam Ion_trans 1275 1548
transmembrane n/a 1277 1295
transmembrane n/a 1315 1336
low_complexity n/a 1347 1368
transmembrane n/a 1348 1367
low_complexity n/a 1373 1389
transmembrane n/a 1412 1434
low_complexity n/a 1414 1427
transmembrane n/a 1514 1537
coiled_coil n/a 1546 1573
disorder n/a 1547 1549
low_complexity n/a 1547 1567
disorder n/a 1551 1558
low_complexity n/a 1576 1587
Pfam Ion_trans 1610 1862
transmembrane n/a 1612 1633
transmembrane n/a 1645 1668
transmembrane n/a 1680 1701
transmembrane n/a 1722 1740
low_complexity n/a 1745 1760
transmembrane n/a 1746 1765
transmembrane n/a 1829 1851
coiled_coil n/a 1850 1874
low_complexity n/a 1853 1877
disorder n/a 1859 1879
disorder n/a 1887 1920
disorder n/a 1949 1984
disorder n/a 1996 2002
disorder n/a 2011 2042
disorder n/a 2045 2073
disorder n/a 2075 2083
disorder n/a 2089 2099
disorder n/a 2101 2158
disorder n/a 2164 2250
disorder n/a 2254 2263
disorder n/a 2265 2377

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43497. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG
50
51
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM
100
101
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
150
151
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
200
201
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
250
251
LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL
300
301
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
350
351
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
400
401
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
450
451
LAQVSRAAGV RVGLLSSPAP LGGQETQPSS SCSRSHRRLS VHHLVHHHHH
500
501
HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP ALSGAPPGGA
550
551
ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE
600
601
TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI
650
651
SSPCLKADSG ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA
700
701
QHSDLRDPHS RRQRSLGPDA EPSSVLAFWR LICDTFRKIV DSKYFGRGIM
750
751
IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM LLKLLVYGPF
800
801
GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA
850
851
LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
900
901
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF
950
951
GNYVLFNLLV AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE
1000
1001
SEPDFFSPSL DGDGDRKKCL ALVSLGEHPE LRKSLLPPLI IHTAATPMSL
1050
1051
PKSTSTGLGE ALGPASRRTS SSGSAEPGAA HEMKSPPSAR SSPHSPWSAA
1100
1101
SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ DEEESSEEER
1150
1151
ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN
1200
1201
GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE
1250
1251
RDSWSAYIFP PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI
1300
1301
DPHSAERIFL TLSNYIFTAV FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD
1350
1351
GLLVLISVID ILVSMVSDSG TKILGMLRVL RLLRTLRPLR VISRAQGLKL
1400
1401
VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGEDTRNIT
1450
1451
NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG
1500
1501
VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE
1550
1551
EARRREEKRL RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF
1600
1601
RLLVHHLCTS HYLDLFITGV IGLNVVTMAM EHYQQPQILD EALKICNYIF
1650
1651
TVIFVLESVF KLVAFGFRRF FQDRWNQLDL AIVLLSIMGI TLEEIEVNAS
1700
1701
LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL PQVGNLGLLF
1750
1751
MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST
1800
1801
GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL
1850
1851
MKHLEESNKE AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS
1900
1901
PDSPKPGALH PAAHARSASH FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM
1950
1951
DELAGPGGQP SAFPSAPSLG GSDPQIPLAE MEALSLTSEI VSEPSCSLAL
2000
2001
TDDSLPDDMH TLLLSALESN MQPHPTELPG PDLLTVRKSG VSRTHSLPND
2050
2051
SYMCRHGSTA EGPLGHRGWG LPKAQSGSVL SVHSQPADTS YILQLPKDAP
2100
2101
HLLQPHSAPT WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE
2150
2151
DLLAEVSGPS PPLARAYSFW GQSSTQAQQH SRSHSKISKH MTPPAPCPGP
2200
2201
EPNWGKGPPE TRSSLELDTE LSWISGDLLP PGGQEEPPSP RDLKKCYSVE
2250
2251
AQSCQRRPTS WLDEQRRHSI AVSCLDSGSQ PHLGTDPSNL GGQPLGGPGS
2300
2301
RPKKKLSPPS ITIDPPESQG PRTPPSPGIC LRRRAPSSDS KDPLASGPPD
2350
2351
SMAASPSPKK DVLSLSGLSS DPADLDP                         
2377
 

Show the unformatted sequence.

Checksums:
CRC64:1C9F7C557D9D32DF
MD5:0c5214ff3dfc34253d349d233627af2c

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.