Summary
This is the summary of UniProt entry CAC1G_HUMAN (O43497).
| Description: | Voltage-dependent T-type calcium channel subunit alpha-1G |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 2377 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 45 |
| low_complexity | n/a | 1 | 11 |
| low_complexity | n/a | 25 | 36 |
| Pfam | Ion_trans | 80 | 406 |
| transmembrane | n/a | 82 | 101 |
| low_complexity | n/a | 118 | 128 |
| transmembrane | n/a | 122 | 142 |
| low_complexity | n/a | 199 | 210 |
| transmembrane | n/a | 214 | 237 |
| low_complexity | n/a | 218 | 229 |
| low_complexity | n/a | 289 | 298 |
| transmembrane | n/a | 342 | 363 |
| low_complexity | n/a | 368 | 379 |
| transmembrane | n/a | 369 | 394 |
| disorder | n/a | 469 | 470 |
| disorder | n/a | 473 | 551 |
| low_complexity | n/a | 478 | 506 |
| disorder | n/a | 553 | 556 |
| disorder | n/a | 567 | 636 |
| disorder | n/a | 680 | 684 |
| disorder | n/a | 686 | 716 |
| Pfam | Ion_trans | 742 | 975 |
| transmembrane | n/a | 744 | 762 |
| transmembrane | n/a | 774 | 795 |
| transmembrane | n/a | 807 | 823 |
| transmembrane | n/a | 865 | 884 |
| low_complexity | n/a | 869 | 883 |
| transmembrane | n/a | 905 | 921 |
| transmembrane | n/a | 941 | 964 |
| disorder | n/a | 991 | 994 |
| disorder | n/a | 996 | 1008 |
| disorder | n/a | 1036 | 1038 |
| disorder | n/a | 1045 | 1228 |
| low_complexity | n/a | 1084 | 1111 |
| low_complexity | n/a | 1132 | 1148 |
| low_complexity | n/a | 1206 | 1225 |
| Pfam | Ion_trans | 1275 | 1548 |
| transmembrane | n/a | 1277 | 1295 |
| transmembrane | n/a | 1315 | 1336 |
| low_complexity | n/a | 1347 | 1368 |
| transmembrane | n/a | 1348 | 1367 |
| low_complexity | n/a | 1373 | 1389 |
| transmembrane | n/a | 1412 | 1434 |
| low_complexity | n/a | 1414 | 1427 |
| transmembrane | n/a | 1514 | 1537 |
| coiled_coil | n/a | 1546 | 1573 |
| disorder | n/a | 1547 | 1549 |
| low_complexity | n/a | 1547 | 1567 |
| disorder | n/a | 1551 | 1558 |
| low_complexity | n/a | 1576 | 1587 |
| Pfam | Ion_trans | 1610 | 1862 |
| transmembrane | n/a | 1612 | 1633 |
| transmembrane | n/a | 1645 | 1668 |
| transmembrane | n/a | 1680 | 1701 |
| transmembrane | n/a | 1722 | 1740 |
| low_complexity | n/a | 1745 | 1760 |
| transmembrane | n/a | 1746 | 1765 |
| transmembrane | n/a | 1829 | 1851 |
| coiled_coil | n/a | 1850 | 1874 |
| low_complexity | n/a | 1853 | 1877 |
| disorder | n/a | 1859 | 1879 |
| disorder | n/a | 1887 | 1920 |
| disorder | n/a | 1949 | 1984 |
| disorder | n/a | 1996 | 2002 |
| disorder | n/a | 2011 | 2042 |
| disorder | n/a | 2045 | 2073 |
| disorder | n/a | 2075 | 2083 |
| disorder | n/a | 2089 | 2099 |
| disorder | n/a | 2101 | 2158 |
| disorder | n/a | 2164 | 2250 |
| disorder | n/a | 2254 | 2263 |
| disorder | n/a | 2265 | 2377 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O43497. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG
50 51
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM
100 101
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
150 151
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
200 201
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
250 251
LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL
300 301
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
350 351
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
400 401
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
450 451
LAQVSRAAGV RVGLLSSPAP LGGQETQPSS SCSRSHRRLS VHHLVHHHHH
500 501
HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP ALSGAPPGGA
550 551
ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE
600 601
TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI
650 651
SSPCLKADSG ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA
700 701
QHSDLRDPHS RRQRSLGPDA EPSSVLAFWR LICDTFRKIV DSKYFGRGIM
750 751
IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM LLKLLVYGPF
800 801
GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA
850 851
LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
900 901
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF
950 951
GNYVLFNLLV AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE
1000 1001
SEPDFFSPSL DGDGDRKKCL ALVSLGEHPE LRKSLLPPLI IHTAATPMSL
1050 1051
PKSTSTGLGE ALGPASRRTS SSGSAEPGAA HEMKSPPSAR SSPHSPWSAA
1100 1101
SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ DEEESSEEER
1150 1151
ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN
1200 1201
GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE
1250 1251
RDSWSAYIFP PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI
1300 1301
DPHSAERIFL TLSNYIFTAV FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD
1350 1351
GLLVLISVID ILVSMVSDSG TKILGMLRVL RLLRTLRPLR VISRAQGLKL
1400 1401
VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGEDTRNIT
1450 1451
NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG
1500 1501
VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE
1550 1551
EARRREEKRL RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF
1600 1601
RLLVHHLCTS HYLDLFITGV IGLNVVTMAM EHYQQPQILD EALKICNYIF
1650 1651
TVIFVLESVF KLVAFGFRRF FQDRWNQLDL AIVLLSIMGI TLEEIEVNAS
1700 1701
LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL PQVGNLGLLF
1750 1751
MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST
1800 1801
GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL
1850 1851
MKHLEESNKE AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS
1900 1901
PDSPKPGALH PAAHARSASH FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM
1950 1951
DELAGPGGQP SAFPSAPSLG GSDPQIPLAE MEALSLTSEI VSEPSCSLAL
2000 2001
TDDSLPDDMH TLLLSALESN MQPHPTELPG PDLLTVRKSG VSRTHSLPND
2050 2051
SYMCRHGSTA EGPLGHRGWG LPKAQSGSVL SVHSQPADTS YILQLPKDAP
2100 2101
HLLQPHSAPT WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE
2150 2151
DLLAEVSGPS PPLARAYSFW GQSSTQAQQH SRSHSKISKH MTPPAPCPGP
2200 2201
EPNWGKGPPE TRSSLELDTE LSWISGDLLP PGGQEEPPSP RDLKKCYSVE
2250 2251
AQSCQRRPTS WLDEQRRHSI AVSCLDSGSQ PHLGTDPSNL GGQPLGGPGS
2300 2301
RPKKKLSPPS ITIDPPESQG PRTPPSPGIC LRRRAPSSDS KDPLASGPPD
2350 2351
SMAASPSPKK DVLSLSGLSS DPADLDP
2377
Show the unformatted sequence. |
| Checksums: |
CRC64:1C9F7C557D9D32DF
MD5:0c5214ff3dfc34253d349d233627af2c
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
