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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FOXO3_HUMAN (O43524)

Summary

This is the summary of UniProt entry FOXO3_HUMAN (O43524).

Description: Forkhead box protein O3 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 673 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 153
low_complexity n/a 1 14
low_complexity n/a 58 70
low_complexity n/a 68 93
low_complexity n/a 120 146
Pfam Forkhead 157 244
disorder n/a 201 209
disorder n/a 217 222
disorder n/a 231 242
disorder n/a 244 312
low_complexity n/a 266 272
disorder n/a 314 352
low_complexity n/a 341 358
disorder n/a 357 423
disorder n/a 425 467
Pfam FOXO_KIX_bdg 432 511
low_complexity n/a 467 482
disorder n/a 470 553
low_complexity n/a 529 538
disorder n/a 555 585
low_complexity n/a 582 598
Pfam FOXO-TAD 604 645
disorder n/a 670 673

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43524. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEAPASPAP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE
50
51
TAADSMIPEE EDDEDDEDGG GRAGSAMAIG GGGGSGTLGS GLLLEDSARV
100
101
LAPGGQDPGS GPATAAGGLS GGTQALLQPQ QPLPPPQPGA AGGSGQPRKC
150
151
SSRRNAWGNL SYADLITRAI ESSPDKRLTL SQIYEWMVRC VPYFKDKGDS
200
201
NSSAGWKNSI RHNLSLHSRF MRVQNEGTGK SSWWIINPDG GKSGKAPRRR
250
251
AVSMDNSNKY TKSRGRAAKK KAALQTAPES ADDSPSQLSK WPGSPTSRSS
300
301
DELDAWTDFR SRTNSNASTV SGRLSPIMAS TELDEVQDDD APLSPMLYSS
350
351
SASLSPSVSK PCTVELPRLT DMAGTMNLND GLTENLMDDL LDNITLPPSQ
400
401
PSPTGGLMQR SSSFPYTTKG SGLGSPTSSF NSTVFGPSSL NSLRQSPMQT
450
451
IQENKPATFS SMSHYGNQTL QDLLTSDSLS HSDVMMTQSD PLMSQASTAV
500
501
SAQNSRRNVM LRNDPMMSFA AQPNQGSLVN QNLLHHQHQT QGALGGSRAL
550
551
SNSVSNMGLS ESSSLGSAKH QQQSPVSQSM QTLSDSLSGS SLYSTSANLP
600
601
VMGHEKFPSD LDLDMFNGSL ECDMESIIRS ELMDADGLDF NFDSLISTQN
650
651
VVGLNVGNFT GAKQASSQSW VPG                             
673
 

Show the unformatted sequence.

Checksums:
CRC64:E5B4E830665A9982
MD5:54a8fb9d2db572d0504ac9a0c799b6ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Forkhead 157 - 244 2K86 A 157 - 244 Jmol OpenAstexViewer
158 - 244 2UZK A 158 - 244 Jmol OpenAstexViewer
C 1158 - 1244 Jmol OpenAstexViewer
237 - 244 6MNL A 1 - 8 Jmol OpenAstexViewer
FOXO_KIX_bdg 460 - 483 2LQH B 101 - 124 Jmol OpenAstexViewer
2LQI B 101 - 124 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.