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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SMAD6_HUMAN (O43541)

Summary

This is the summary of UniProt entry SMAD6_HUMAN (O43541).

Description: Mothers against decapentaplegic homolog 6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 496 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 2
disorder n/a 5 6
disorder n/a 9 116
low_complexity n/a 20 40
low_complexity n/a 59 71
low_complexity n/a 72 91
disorder n/a 132 133
disorder n/a 137 154
low_complexity n/a 143 155
low_complexity n/a 152 168
disorder n/a 160 162
Pfam MH1 172 270
low_complexity n/a 212 228
low_complexity n/a 271 283
disorder n/a 276 286
disorder n/a 293 294
disorder n/a 311 313
disorder n/a 316 319
Pfam MH2 329 493
disorder n/a 450 457

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43541. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFRSKRSGLV RRLWRSRVVP DREEGGSGGG GGGDEDGSLG SRAEPAPRAR
50
51
EGGGCGRSEV RPVAPRRPRD AVGQRGAQGA GRRRRAGGPP RPMSEPGAGA
100
101
GSSLLDVAEP GGPGWLPESD CETVTCCLFS ERDAAGAPRD ASDPLAGAAL
150
151
EPAGGGRSRE ARSRLLLLEQ ELKTVTYSLL KRLKERSLDT LLEAVESRGG
200
201
VPGGCVLVPR ADLRLGGQPA PPQLLLGRLF RWPDLQHAVE LKPLCGCHSF
250
251
AAAADGPTVC CNPYHFSRLC GPESPPPPYS RLSPRDEYKP LDLSDSTLSY
300
301
TETEATNSLI TAPGEFSDAS MSPDATKPSH WCSVAYWEHR TRVGRLYAVY
350
351
DQAVSIFYDL PQGSGFCLGQ LNLEQRSESV RRTRSKIGFG ILLSKEPDGV
400
401
WAYNRGEHPI FVNSPTLDAP GGRALVVRKV PPGYSIKVFD FERSGLQHAP
450
451
EPDAADGPYD PNSVRISFAK GWGPCYSRQF ITSCPCWLEI LLNNPR    
496
 

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Checksums:
CRC64:A4B928AE2D34EBC2
MD5:b4e392254c3d07625b6e16fe5ae53f56

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.