Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CAH12_HUMAN (O43570)

Summary

This is the summary of UniProt entry CAH12_HUMAN (O43570).

Description: Carbonic anhydrase 12 EC=4.2.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 354 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 29
low_complexity n/a 7 14
disorder n/a 28 31
Pfam Carb_anhydrase 31 288
disorder n/a 120 135
low_complexity n/a 296 315
transmembrane n/a 300 327
disorder n/a 353 354

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43570. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC
50
51
GGLLQSPIDL HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL
100
101
PSDMHIQGLQ SRYSATQLHL HWGNPNDPHG SEHTVSGQHF AAELHIVHYN
150
151
SDLYPDASTA SNKSEGLAVL AVLIEMGSFN PSYDKIFSHL QHVKYKGQEA
200
201
FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR NPVQISQEQL
250
251
LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL
300
301
SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET
350
351
EAHA                                                  
354
 

Show the unformatted sequence.

Checksums:
CRC64:9016216BF2CA6C0C
MD5:e5c4f834d5d831ea0f965235a7191ae2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Carb_anhydrase 31 - 288 1JCZ A 4 - 259 Jmol OpenAstexViewer
B 4 - 259 Jmol OpenAstexViewer
1JD0 A 4 - 259 Jmol OpenAstexViewer
4HT2 A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
4KP5 A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
4KP8 A 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
4Q0L A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
4QJ0 A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
4QJO A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
4QJW A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
4WW8 A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
5LL5 A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
5LL9 A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
5LLO A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
5LLP A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
5MSA A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
5MSB A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
6G5L A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
6G7A A 3 - 260 Jmol OpenAstexViewer
B 3 - 260 Jmol OpenAstexViewer
C 3 - 260 Jmol OpenAstexViewer
D 3 - 260 Jmol OpenAstexViewer
6RPS A 4 - 259 Jmol OpenAstexViewer
B 4 - 259 Jmol OpenAstexViewer
32 - 288 1JD0 B 5 - 259 Jmol OpenAstexViewer
4KP8 B 4 - 260 Jmol OpenAstexViewer
D 4 - 260 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.