Summary
This is the summary of UniProt entry CAH12_HUMAN (O43570).
Description: | Carbonic anhydrase 12 EC=4.2.1.1 |
Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
Length: | 354 amino acids |
Reference Proteome: |
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Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
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Source | Domain | Start | End |
---|---|---|---|
sig_p | n/a | 1 | 29 |
low_complexity | n/a | 7 | 14 |
disorder | n/a | 28 | 31 |
Pfam | Carb_anhydrase | 31 | 288 |
disorder | n/a | 120 | 135 |
low_complexity | n/a | 296 | 315 |
transmembrane | n/a | 300 | 327 |
disorder | n/a | 353 | 354 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O43570. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
Sequence: | 1
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC
50 51
GGLLQSPIDL HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL
100 101
PSDMHIQGLQ SRYSATQLHL HWGNPNDPHG SEHTVSGQHF AAELHIVHYN
150 151
SDLYPDASTA SNKSEGLAVL AVLIEMGSFN PSYDKIFSHL QHVKYKGQEA
200 201
FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR NPVQISQEQL
250 251
LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL
300 301
SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET
350 351
EAHA
354
Show the unformatted sequence. |
Checksums: |
CRC64:9016216BF2CA6C0C
MD5:e5c4f834d5d831ea0f965235a7191ae2
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.