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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: CHP2_HUMAN (O43745)

Summary

This is the summary of UniProt entry CHP2_HUMAN (O43745).

Description: Calcineurin B homologous protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 196 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 16
Pfam EF-hand_5 31 54
disorder n/a 94 111
Pfam EF-hand_1 115 143
disorder n/a 155 162

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43745. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGSRSSHAAV IPDGDSIRRE TGFSQASLLR LHHRFRALDR NKKGYLSRMD
50
51
LQQIGALAVN PLGDRIIESF FPDGSQRVDF PGFVRVLAHF RPVEDEDTET
100
101
QDPKKPEPLN SRRNKLHYAF QLYDLDRDGK ISRHEMLQVL RLMVGVQVTE
150
151
EQLENIADRT VQEADEDGDG AVSFVEFTKS LEKMDVEQKM SIRILK    
196
 

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Checksums:
CRC64:F5113D558AFA27DE
MD5:d14f89c41fdc7b840e1a1d5d077aa060

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EF-hand_1 115 - 143 2BEC A 115 - 143 Jmol OpenAstexViewer
EF-hand_5 31 - 54 2BEC A 31 - 54 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.