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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPOP_HUMAN (O43791)

Summary

This is the summary of UniProt entry SPOP_HUMAN (O43791).

Description: Speckle-type POZ protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 374 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 11
Pfam MATH 38 163
Pfam BTB 190 297
low_complexity n/a 265 281

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43791. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE
50
51
VIKSSTFSSG ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA
100
101
KFKFSILNAK GEETKAMESQ RAYRFVQGKD WGFKKFIRRD FLLDEANGLL
150
151
PDDKLTLFCE VSVVQDSVNI SGQNTMNMVK VPECRLADEL GGLWENSRFT
200
201
DCCLCVAGQE FQAHKAILAA RSPVFSAMFE HEMEESKKNR VEINDVEPEV
250
251
FKEMMCFIYT GKAPNLDKMA DDLLAAADKY ALERLKVMCE DALCSNLSVE
300
301
NAAEILILAD LHSADQLKTQ AVDFINYHAS DVLETSGWKS MVVSHPHLVA
350
351
EAYRSLASAQ CPFLGPPRKR LKQS                            
374
 

Show the unformatted sequence.

Checksums:
CRC64:EE5F4C5CF6FD09DC
MD5:26ad33307e9d9e0f62e843dc946cba41

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BTB 190 - 292 4EOZ A 190 - 292 Jmol OpenAstexViewer
190 - 295 4EOZ C 190 - 295 Jmol OpenAstexViewer
190 - 297 3HQI A 190 - 297 Jmol OpenAstexViewer
B 190 - 297 Jmol OpenAstexViewer
3HTM A 190 - 297 Jmol OpenAstexViewer
B 190 - 297 Jmol OpenAstexViewer
C 190 - 297 Jmol OpenAstexViewer
D 190 - 297 Jmol OpenAstexViewer
3HU6 A 190 - 297 Jmol OpenAstexViewer
B 190 - 297 Jmol OpenAstexViewer
4J8Z A 190 - 297 Jmol OpenAstexViewer
B 190 - 297 Jmol OpenAstexViewer
296 - 297 4HS2 A 296 - 297 Jmol OpenAstexViewer
MATH 38 - 163 2CR2 A 18 - 143 Jmol OpenAstexViewer
3HQH A 38 - 163 Jmol OpenAstexViewer
3HQI A 38 - 163 Jmol OpenAstexViewer
B 38 - 163 Jmol OpenAstexViewer
3HQL A 38 - 163 Jmol OpenAstexViewer
B 38 - 163 Jmol OpenAstexViewer
3HQM A 38 - 163 Jmol OpenAstexViewer
B 38 - 163 Jmol OpenAstexViewer
3HU6 A 38 - 163 Jmol OpenAstexViewer
B 38 - 163 Jmol OpenAstexViewer
3IVB A 38 - 163 Jmol OpenAstexViewer
3IVQ A 38 - 163 Jmol OpenAstexViewer
B 38 - 163 Jmol OpenAstexViewer
3IVV A 38 - 163 Jmol OpenAstexViewer
4O1V A 38 - 163 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.