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21  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CPSF5_HUMAN (O43809)

Summary

This is the summary of UniProt entry CPSF5_HUMAN (O43809).

Description: Cleavage and polyadenylation specificity factor subunit 5 {ECO:0000303|PubMed:23187700}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 227 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 3 8
disorder n/a 11 12
Pfam NUDIX_2 35 222

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43809. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSVVPPNRSQ TGWPRGVTQF GNKYIQQTKP LTLERTINLY PLTNYTFGTK
50
51
EPLYEKDSSV AARFQRMREE FDKIGMRRTV EGVLIVHEHR LPHVLLLQLG
100
101
TTFFKLPGGE LNPGEDEVEG LKRLMTEILG RQDGVLQDWV IDDCIGNWWR
150
151
PNFEPPQYPY IPAHITKPKE HKKLFLVQLQ EKALFAVPKN YKLVAAPLFE
200
201
LYDNAPGYGP IISSLPQLLS RFNFIYN                         
227
 

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Checksums:
CRC64:D204243E57F1CCC5
MD5:f51a91b82c7c64d16d852a603241d140

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NUDIX_2 35 - 222 2CL3 A 35 - 222 Show 3D Structure View in InterPro
2J8Q A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
3BAP A 35 - 222 Show 3D Structure View in InterPro
3BHO A 35 - 222 Show 3D Structure View in InterPro
3MDG A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
3MDI A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
3N9U A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
3P5T A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
C 35 - 222 Show 3D Structure View in InterPro
D 35 - 222 Show 3D Structure View in InterPro
E 35 - 222 Show 3D Structure View in InterPro
F 35 - 222 Show 3D Structure View in InterPro
3P6Y A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
E 35 - 222 Show 3D Structure View in InterPro
F 35 - 222 Show 3D Structure View in InterPro
I 35 - 222 Show 3D Structure View in InterPro
J 35 - 222 Show 3D Structure View in InterPro
M 35 - 222 Show 3D Structure View in InterPro
N 35 - 222 Show 3D Structure View in InterPro
3Q2S A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
3Q2T A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R4P A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R4Q A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R4R A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R4S A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R4T A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R4U A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R64 A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R65 A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R66 A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
5R67 A 35 - 222 Show 3D Structure View in InterPro
B 35 - 222 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;