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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: EDIL3_HUMAN (O43854)

Summary

This is the summary of UniProt entry EDIL3_HUMAN (O43854).

Description: EGF-like repeat and discoidin I-like domain-containing protein 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 480 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
Pfam EGF 26 58
low_complexity n/a 59 70
Pfam EGF 78 115
Pfam hEGF 128 146
Pfam F5_F8_type_C 173 311
Pfam F5_F8_type_C 334 473
disorder n/a 362 365
disorder n/a 433 435

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43854. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKRSVAVWLL VGLSLGVPQF GKGDICDPNP CENGGICLPG LADGSFSCEC
50
51
PDGFTDPNCS SVVEVASDEE EPTSAGPCTP NPCHNGGTCE ISEAYRGDTF
100
101
IGYVCKCPRG FNGIHCQHNI NECEVEPCKN GGICTDLVAN YSCECPGEFM
150
151
GRNCQYKCSG PLGIEGGIIS NQQITASSTH RALFGLQKWY PYYARLNKKG
200
201
LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP EYIKSYKIAY
250
251
SNDGKTWAMY KVKGTNEDMV FRGNIDNNTP YANSFTPPIK AQYVRLYPQV
300
301
CRRHCTLRME LLGCELSGCS EPLGMKSGHI QDYQITASSI FRTLNMDMFT
350
351
WEPRKARLDK QGKVNAWTSG HNDQSQWLQV DLLVPTKVTG IITQGAKDFG
400
401
HVQFVGSYKL AYSNDGEHWT VYQDEKQRKD KVFQGNFDND THRKNVIDPP
450
451
IYARHIRILP WSWYGRITLR SELLGCTEEE                      
480
 

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Checksums:
CRC64:F7171E23A309FD48
MD5:6ef4f8701ce2bce118c9ff7dc6d10091

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EGF 26 - 58 4D90 A 26 - 58 Jmol OpenAstexViewer
B 26 - 58 Jmol OpenAstexViewer
78 - 115 4D90 A 78 - 115 Jmol OpenAstexViewer
B 78 - 115 Jmol OpenAstexViewer
hEGF 128 - 146 4D90 A 128 - 146 Jmol OpenAstexViewer
B 128 - 146 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.