Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PARG_DROME (O46043)

Summary

This is the summary of UniProt entry PARG_DROME (O46043).

Description: Poly(ADP-ribose) glycohydrolase
Source organism: Drosophila melanogaster (Fruit fly) (NCBI taxonomy ID 7227)
Length: 723 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 29
low_complexity n/a 11 19
disorder n/a 31 34
disorder n/a 36 37
disorder n/a 40 50
disorder n/a 60 62
disorder n/a 66 68
disorder n/a 71 83
disorder n/a 85 98
disorder n/a 100 101
Pfam PARG_cat 155 492
low_complexity n/a 166 182
low_complexity n/a 196 208
disorder n/a 392 393
disorder n/a 525 531
disorder n/a 554 723
low_complexity n/a 626 642
low_complexity n/a 644 655
low_complexity n/a 649 664

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O46043. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSKSPDGGIS EIETEEEPEN LANSLDDSWR GVSMEAIHRN RQPFELENLP
50
51
PVTAGNLHRV MYQLPIRETP PRPYKSPGKW DSEHVRLPCA PESKYPRENP
100
101
DGSTTIDFRW EMIERALLQP IKTCEELQAA IISYNTTYRD QWHFRALHQL
150
151
LDEELDESET RVFFEDLLPR IIRLALRLPD LIQSPVPLLK HHKNASLSLS
200
201
QQQISCLLAN AFLCTFPRRN TLKRKSEYST FPDINFNRLY QSTGPAVLEK
250
251
LKCIMHYFRR VCPTERDASN VPTGVVTFVR RSGLPEHLID WSQSAAPLGD
300
301
VPLHVDAEGT IEDEGIGLLQ VDFANKYLGG GVLGHGCVQE EIRFVICPEL
350
351
LVGKLFTECL RPFEALVMLG AERYSNYTGY AGSFEWSGNF EDSTPRDSSG
400
401
RRQTAIVAID ALHFAQSHHQ YREDLMEREL NKAYIGFVHW MVTPPPGVAT
450
451
GNWGCGAFGG DSYLKALLQL MVCAQLGRPL AYYTFGNVEF RDDFHEMWLL
500
501
FRNDGTTVQQ LWSILRSYSR LIKEKSSKEP RENKASKKKL YDFIKEELKK
550
551
VRDVPGEGAS AEAGSSRVAG LGEGKSETSA KSSPELNKQP ARPQITITQQ
600
601
STDLLPAQLS QDNSNSSEDQ ALLMLSDDEE ANAMMEAASL EAKSSVEISN
650
651
SSTTSKTSST ATKSMGSGGR QLSLLEMLDT HYEKGSASKR PRKSPNCSKA
700
701
EGSAKSRKEI DVTDKDEKDD IVD                             
723
 

Show the unformatted sequence.

Checksums:
CRC64:90A5BA59775D611C
MD5:d53908fe90070447ba6a26fdfbd272df

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;