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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CATH_PIG (O46427)

Summary

This is the summary of UniProt entry CATH_PIG (O46427).

Description: Pro-cathepsin H EC=3.4.22.16
Source organism: Sus scrofa (Pig) (NCBI taxonomy ID 9823)
Length: 335 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
Pfam Inhibitor_I29 35 90
Pfam Peptidase_C1 116 332

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O46427. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MWAVLSLLCA GAWLLGPPAC GASNLAVSSF EKLHFKSWMV QHQKKYSLEE
50
51
YHHRLQVFVS NWRKINAHNA GNHTFKLGLN QFSDMSFDEI RHKYLWSEPQ
100
101
NCSATKGNYL RGTGPYPPSM DWRKKGNFVS PVKNQGSCGS CWTFSTTGAL
150
151
ESAVAIATGK MLSLAEQQLV DCAQNFNNHG CQGGLPSQAF EYIRYNKGIM
200
201
GEDTYPYKGQ DDHCKFQPDK AIAFVKDVAN ITMNDEEAMV EAVALYNPVS
250
251
FAFEVTNDFL MYRKGIYSST SCHKTPDKVN HAVLAVGYGE ENGIPYWIVK
300
301
NSWGPQWGMN GYFLIERGKN MCGLAACASY PIPLV                
335
 

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Checksums:
CRC64:F728EB45292C3B55
MD5:2394553ec252aba22a4d886b86ff19f7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_C1 116 - 332 1NB3 A 1 - 210 Jmol OpenAstexViewer
B 1 - 210 Jmol OpenAstexViewer
C 1 - 210 Jmol OpenAstexViewer
D 1 - 210 Jmol OpenAstexViewer
1NB5 A 1 - 210 Jmol OpenAstexViewer
B 1 - 210 Jmol OpenAstexViewer
C 1 - 210 Jmol OpenAstexViewer
D 1 - 210 Jmol OpenAstexViewer
8PCH A 1 - 210 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.