Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AK1BA_HUMAN (O60218)

Summary

This is the summary of UniProt entry AK1BA_HUMAN (O60218).

Description: Aldo-keto reductase family 1 member B10 EC=1.1.1.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 316 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Aldo_ket_red 15 294
disorder n/a 221 222
disorder n/a 224 225

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60218. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ
50
51
NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL
100
101
KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD
150
151
EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC
200
201
HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI
250
251
RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN
300
301
VLQSSHLEDY PFNAEY                                     
316
 

Show the unformatted sequence.

Checksums:
CRC64:0C2FC0E798955A33
MD5:aa4954b32b1588abc52c03e8bafffb29

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aldo_ket_red 15 - 294 1ZUA X 15 - 294 Jmol OpenAstexViewer
4GA8 A 15 - 294 Jmol OpenAstexViewer
4GAB A 15 - 294 Jmol OpenAstexViewer
4GQ0 A 15 - 294 Jmol OpenAstexViewer
4GQG A 15 - 294 Jmol OpenAstexViewer
4I5X A 15 - 294 Jmol OpenAstexViewer
4ICC X 15 - 294 Jmol OpenAstexViewer
4JIH A 15 - 294 Jmol OpenAstexViewer
4JII X 15 - 294 Jmol OpenAstexViewer
4WEV X 15 - 294 Jmol OpenAstexViewer
4XZL X 15 - 294 Jmol OpenAstexViewer
4XZM X 15 - 294 Jmol OpenAstexViewer
4XZN X 15 - 294 Jmol OpenAstexViewer
5LIK X 15 - 294 Jmol OpenAstexViewer
5LIU X 15 - 294 Jmol OpenAstexViewer
5LIW X 15 - 294 Jmol OpenAstexViewer
5LIX X 15 - 294 Jmol OpenAstexViewer
5LIY X 15 - 294 Jmol OpenAstexViewer
5M2F X 15 - 294 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.