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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DLX3_HUMAN (O60479)

Summary

This is the summary of UniProt entry DLX3_HUMAN (O60479).

Description: Homeobox protein DLX-3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 287 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 8 20
disorder n/a 23 31
Pfam DLL_N 27 108
disorder n/a 33 39
disorder n/a 55 57
disorder n/a 103 127
Pfam Homeodomain 130 186
disorder n/a 187 240
low_complexity n/a 230 243
disorder n/a 242 244
disorder n/a 248 287

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60479. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESSVTDL GYYSAPQHDY
50
51
YSGQPYGQTV NPYTYHHQFN LNGLAGTGAY SPKSEYTYGA SYRQYGAYRE
100
101
QPLPAQDPVS VKEEPEAEVR MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK
150
151
AQYLALPERA ELAAQLGLTQ TQVKIWFQNR RSKFKKLYKN GEVPLEHSPN
200
201
NSDSMACNSP PSPALWDTSS HSTPAPARSQ LPPPLPYSAS PSYLDDPTNS
250
251
WYHAQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY              
287
 

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Checksums:
CRC64:DCA9716E51D78DD1
MD5:90432836defdb449bd991d5789c13cd0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Homeodomain 131 - 186 4XRS G 131 - 186 Jmol OpenAstexViewer
I 131 - 186 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.