Summary
This is the summary of UniProt entry CUBN_HUMAN (O60494).
| Description: | Cubilin {ECO:0000303|PubMed:9572993} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 3623 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 23 |
| low_complexity | n/a | 6 | 16 |
| coiled_coil | n/a | 110 | 130 |
| Pfam | EGF | 136 | 166 |
| Pfam | EGF_CA | 170 | 217 |
| Pfam | EGF_CA | 263 | 303 |
| Pfam | EGF_CA | 305 | 347 |
| Pfam | EGF_3 | 353 | 388 |
| low_complexity | n/a | 380 | 391 |
| Pfam | EGF | 399 | 428 |
| Pfam | EGF | 436 | 466 |
| Pfam | CUB | 474 | 583 |
| Pfam | CUB | 590 | 699 |
| Pfam | CUB | 708 | 813 |
| Pfam | CUB | 817 | 925 |
| Pfam | CUB | 932 | 1039 |
| Pfam | CUB | 1048 | 1158 |
| Pfam | CUB | 1165 | 1274 |
| Pfam | CUB | 1278 | 1386 |
| disorder | n/a | 1352 | 1354 |
| Pfam | CUB | 1391 | 1503 |
| disorder | n/a | 1402 | 1405 |
| disorder | n/a | 1463 | 1465 |
| disorder | n/a | 1468 | 1474 |
| disorder | n/a | 1476 | 1480 |
| Pfam | CUB | 1510 | 1616 |
| disorder | n/a | 1524 | 1526 |
| Pfam | CUB | 1620 | 1731 |
| disorder | n/a | 1693 | 1694 |
| Pfam | CUB | 1738 | 1847 |
| Pfam | CUB | 1852 | 1960 |
| Pfam | CUB | 1978 | 2088 |
| Pfam | CUB | 2092 | 2210 |
| Pfam | CUB | 2217 | 2331 |
| disorder | n/a | 2233 | 2235 |
| Pfam | CUB | 2336 | 2445 |
| Pfam | CUB | 2452 | 2562 |
| disorder | n/a | 2463 | 2466 |
| disorder | n/a | 2474 | 2479 |
| Pfam | CUB | 2570 | 2684 |
| disorder | n/a | 2573 | 2575 |
| Pfam | CUB | 2689 | 2798 |
| disorder | n/a | 2758 | 2760 |
| Pfam | CUB | 2805 | 2916 |
| disorder | n/a | 2816 | 2821 |
| Pfam | CUB | 2920 | 3032 |
| Pfam | CUB | 3037 | 3147 |
| Pfam | CUB | 3157 | 3271 |
| Pfam | CUB | 3278 | 3390 |
| disorder | n/a | 3289 | 3291 |
| disorder | n/a | 3338 | 3339 |
| Pfam | CUB | 3395 | 3504 |
| Pfam | CUB | 3511 | 3621 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O60494. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MMNMSLPFLW SLLTLLIFAE VNGEAGELEL QRQKRSINLQ QPRMATERGN
50 51
LVFLTGSAQN IEFRTGSLGK IKLNDEDLSE CLHQIQKNKE DIIELKGSAI
100 101
GLPQNISSQI YQLNSKLVDL ERKFQGLQQT VDKKVCSSNP CQNGGTCLNL
150 151
HDSFFCICPP QWKGPLCSAD VNECEIYSGT PLSCQNGGTC VNTMGSYSCH
200 201
CPPETYGPQC ASKYDDCEGG SVARCVHGIC EDLMREQAGE PKYSCVCDAG
250 251
WMFSPNSPAC TLDRDECSFQ PGPCSTLVQC FNTQGSFYCG ACPTGWQGNG
300 301
YICEDINECE INNGGCSVAP PVECVNTPGS SHCQACPPGY QGDGRVCTLT
350 351
DICSVSNGGC HPDASCSSTL GSLPLCTCLP GYTGNGYGPN GCVQLSNICL
400 401
SHPCLNGQCI DTVSGYFCKC DSGWTGVNCT ENINECLSNP CLNGGTCVDG
450 451
VDSFSCECTR LWTGALCQVP QQVCGESLSG INGSFSYRSP DVGYVHDVNC
500 501
FWVIKTEMGK VLRITFTFFR LESMDNCPHE FLQVYDGDSS SAFQLGRFCG
550 551
SSLPHELLSS DNALYFHLYS EHLRNGRGFT VRWETQQPEC GGILTGPYGS
600 601
IKSPGYPGNY PPGRDCVWIV VTSPDLLVTF TFGTLSLEHH DDCNKDYLEI
650 651
RDGPLYQDPL LGKFCTTFSV PPLQTTGPFA RIHFHSDSQI SDQGFHITYL
700 701
TSPSDLRCGG NYTDPEGELF LPELSGPFTH TRQCVYMMKQ PQGEQIQINF
750 751
THVELQCQSD SSQNYIEVRD GETLLGKVCG NGTISHIKSI TNSVWIRFKI
800 801
DASVEKASFR AVYQVACGDE LTGEGVIRSP FFPNVYPGER TCRWTIHQPQ
850 851
SQVILLNFTV FEIGSSAHCE TDYVEIGSSS ILGSPENKKY CGTDIPSFIT
900 901
SVYNFLYVTF VKSSSTENHG FMAKFSAEDL ACGEILTEST GTIQSPGHPN
950 951
VYPHGINCTW HILVQPNHLI HLMFETFHLE FHYNCTNDYL EVYDTDSETS
1000 1001
LGRYCGKSIP PSLTSSGNSL MLVFVTDSDL AYEGFLINYE AISAATACLQ
1050 1051
DYTDDLGTFT SPNFPNNYPN NWECIYRITV RTGQLIAVHF TNFSLEEAIG
1100 1101
NYYTDFLEIR DGGYEKSPLL GIFYGSNLPP TIISHSNKLW LKFKSDQIDT
1150 1151
RSGFSAYWDG SSTGCGGNLT TSSGTFISPN YPMPYYHSSE CYWWLKSSHG
1200 1201
SAFELEFKDF HLEHHPNCTL DYLAVYDGPS SNSHLLTQLC GDEKPPLIRS
1250 1251
SGDSMFIKLR TDEGQQGRGF KAEYRQTCEN VVIVNQTYGI LESIGYPNPY
1300 1301
SENQHCNWTI RATTGNTVNY TFLAFDLEHH INCSTDYLEL YDGPRQMGRY
1350 1351
CGVDLPPPGS TTSSKLQVLL LTDGVGRREK GFQMQWFVYG CGGELSGATG
1400 1401
SFSSPGFPNR YPPNKECIWY IRTDPGSSIQ LTIHDFDVEY HSRCNFDVLE
1450 1451
IYGGPDFHSP RIAQLCTQRS PENPMQVSST GNELAIRFKT DLSINGRGFN
1500 1501
ASWQAVTGGC GGIFQAPSGE IHSPNYPSPY RSNTDCSWVI RVDRNHRVLL
1550 1551
NFTDFDLEPQ DSCIMAYDGL SSTMSRLART CGREQLANPI VSSGNSLFLR
1600 1601
FQSGPSRQNR GFRAQFRQAC GGHILTSSFD TVSSPRFPAN YPNNQNCSWI
1650 1651
IQAQPPLNHI TLSFTHFELE RSTTCARDFV EILDGGHEDA PLRGRYCGTD
1700 1701
MPHPITSFSS ALTLRFVSDS SISAGGFHTT VTASVSACGG TFYMAEGIFN
1750 1751
SPGYPDIYPP NVECVWNIVS SPGNRLQLSF ISFQLEDSQD CSRDFVEIRE
1800 1801
GNATGHLVGR YCGNSFPLNY SSIVGHTLWV RFISDGSGSG TGFQATFMKI
1850 1851
FGNDNIVGTH GKVASPFWPE NYPHNSNYQW TVNVNASHVV HGRILEMDIE
1900 1901
EIQNCYYDKL RIYDGPSIHA RLIGAYCGTQ TESFSSTGNS LTFHFYSDSS
1950 1951
ISGKGFLLEW FAVDAPDGVL PTIAPGACGG FLRTGDAPVF LFSPGWPDSY
2000 2001
SNRVDCTWLI QAPDSTVELN ILSLDIESHR TCAYDSLVIR DGDNNLAQQL
2050 2051
AVLCGREIPG PIRSTGEYMF IRFTSDSSVT RAGFNASFHK SCGGYLHADR
2100 2101
GIITSPKYPE TYPSNLNCSW HVLVQSGLTI AVHFEQPFQI PNGDSSCNQG
2150 2151
DYLVLRNGPD ICSPPLGPPG GNGHFCGSHA SSTLFTSDNQ MFVQFISDHS
2200 2201
NEGQGFKIKY EAKSLACGGN VYIHDADSAG YVTSPNHPHN YPPHADCIWI
2250 2251
LAAPPETRIQ LQFEDRFDIE VTPNCTSNYL ELRDGVDSDA PILSKFCGTS
2300 2301
LPSSQWSSGE VMYLRFRSDN SPTHVGFKAK YSIAQCGGRV PGQSGVVESI
2350 2351
GHPTLPYRDN LFCEWHLQGL SGHYLTISFE DFNLQNSSGC EKDFVEIWDN
2400 2401
HTSGNILGRY CGNTIPDSID TSSNTAVVRF VTDGSVTASG FRLRFESSME
2450 2451
ECGGDLQGSI GTFTSPNYPN PNPHGRICEW RITAPEGRRI TLMFNNLRLA
2500 2501
THPSCNNEHV IVFNGIRSNS PQLEKLCSSV NVSNEIKSSG NTMKVIFFTD
2550 2551
GSRPYGGFTA SYTSSEDAVC GGSLPNTPEG NFTSPGYDGV RNYSRNLNCE
2600 2601
WTLSNPNQGN SSISIHFEDF YLESHQDCQF DVLEFRVGDA DGPLMWRLCG
2650 2651
PSKPTLPLVI PYSQVWIHFV TNERVEHIGF HAKYSFTDCG GIQIGDSGVI
2700 2701
TSPNYPNAYD SLTHCSSLLE APQGHTITLT FSDFDIEPHT TCAWDSVTVR
2750 2751
NGGSPESPII GQYCGNSNPR TIQSGSNQLV VTFNSDHSLQ GGGFYATWNT
2800 2801
QTLGCGGIFH SDNGTIRSPH WPQNFPENSR CSWTAITHKS KHLEISFDNN
2850 2851
FLIPSGDGQC QNSFVKVWAG TEEVDKALLA TGCGNVAPGP VITPSNTFTA
2900 2901
VFQSQEAPAQ GFSASFVSRC GSNFTGPSGY IISPNYPKQY DNNMNCTYVI
2950 2951
EANPLSVVLL TFVSFHLEAR SAVTGSCVND GVHIIRGYSV MSTPFATVCG
3000 3001
DEMPAPLTIA GPVLLNFYSN EQITDFGFKF SYRIISCGGV FNFSSGIITS
3050 3051
PAYSYADYPN DMHCLYTITV SDDKVIELKF SDFDVVPSTS CSHDYLAIYD
3100 3101
GANTSDPLLG KFCGSKRPPN VKSSNNSMLL VFKTDSFQTA KGWKMSFRQT
3150 3151
LGPQQGCGGY LTGSNNTFAS PDSDSNGMYD KNLNCVWIII APVNKVIHLT
3200 3201
FNTFALEAAS TRQRCLYDYV KLYDGDSENA NLAGTFCGST VPAPFISSGN
3250 3251
FLTVQFISDL TLEREGFNAT YTIMDMPCGG TYNATWTPQN ISSPNSSDPD
3300 3301
VPFSICTWVI DSPPHQQVKI TVWALQLTSQ DCTQNYLQLQ DSPQGHGNSR
3350 3351
FQFCGRNASA VPVFYSSMST AMVIFKSGVV NRNSRMSFTY QIADCNRDYH
3400 3401
KAFGNLRSPG WPDNYDNDKD CTVTLTAPQN HTISLFFHSL GIENSVECRN
3450 3451
DFLEVRNGSN SNSPLLGKYC GTLLPNPVFS QNNELYLRFK SDSVTSDRGY
3500 3501
EIIWTSSPSG CGGTLYGDRG SFTSPGYPGT YPNNTYCEWV LVAPAGRLVT
3550 3551
INFYFISIDD PGDCVQNYLT LYDGPNASSP SSGPYCGGDT SIAPFVASSN
3600 3601
QVFIKFHADY ARRPSAFRLT WDS
3623
Show the unformatted sequence. |
| Checksums: |
CRC64:8D602663C6D4751F
MD5:1465bbfc27efa701b7290280ac3133d9
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| CUB | 1048 - 1158 | 3KQ4 | B | 1048 - 1158 | Show 3D Structure View in InterPro |
| D | 1048 - 1158 | Show 3D Structure View in InterPro | |||
| F | 1048 - 1158 | Show 3D Structure View in InterPro | |||
| 1165 - 1274 | 3KQ4 | B | 1165 - 1274 | Show 3D Structure View in InterPro | |
| D | 1165 - 1274 | Show 3D Structure View in InterPro | |||
| F | 1165 - 1274 | Show 3D Structure View in InterPro | |||
| 1278 - 1386 | 3KQ4 | B | 1278 - 1386 | Show 3D Structure View in InterPro | |
| D | 1278 - 1386 | Show 3D Structure View in InterPro | |||
| F | 1278 - 1386 | Show 3D Structure View in InterPro | |||
| 932 - 1039 | 3KQ4 | B | 932 - 1039 | Show 3D Structure View in InterPro | |
| D | 932 - 1039 | Show 3D Structure View in InterPro | |||
| F | 932 - 1039 | Show 3D Structure View in InterPro |
The parts of the structure corresponding to the Pfam family are highlighted in blue.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
