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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GMDS_HUMAN (O60547)

Summary

This is the summary of UniProt entry GMDS_HUMAN (O60547).

Description: GDP-mannose 4,6 dehydratase EC=4.2.1.47
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 372 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 2 16
disorder n/a 24 26
Pfam GDP_Man_Dehyd 27 358
disorder n/a 370 372

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60547. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAHAPARCPS ARGSGDGEMG KPRNVALITG ITGQDGSYLA EFLLEKGYEV
50
51
HGIVRRSSSF NTGRIEHLYK NPQAHIEGNM KLHYGDLTDS TCLVKIINEV
100
101
KPTEIYNLGA QSHVKISFDL AEYTADVDGV GTLRLLDAVK TCGLINSVKF
150
151
YQASTSELYG KVQEIPQKET TPFYPRSPYG AAKLYAYWIV VNFREAYNLF
200
201
AVNGILFNHE SPRRGANFVT RKISRSVAKI YLGQLECFSL GNLDAKRDWG
250
251
HAKDYVEAMW LMLQNDEPED FVIATGEVHS VREFVEKSFL HIGKTIVWEG
300
301
KNENEVGRCK ETGKVHVTVD LKYYRPTEVD FLQGDCTKAK QKLNWKPRVA
350
351
FDELVREMVH ADVELMRTNP NA                              
372
 

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Checksums:
CRC64:B1BAC441736D4C2B
MD5:03742d83c14a0e02abbd09b8d7497437

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
GDP_Man_Dehyd 27 - 358 1T2A A 27 - 358 Jmol OpenAstexViewer
B 27 - 358 Jmol OpenAstexViewer
C 27 - 358 Jmol OpenAstexViewer
D 27 - 358 Jmol OpenAstexViewer
5IN4 A 27 - 358 Jmol OpenAstexViewer
B 27 - 358 Jmol OpenAstexViewer
C 27 - 358 Jmol OpenAstexViewer
D 27 - 358 Jmol OpenAstexViewer
5IN5 A 27 - 358 Jmol OpenAstexViewer
B 27 - 358 Jmol OpenAstexViewer
C 27 - 358 Jmol OpenAstexViewer
D 27 - 358 Jmol OpenAstexViewer
6GPJ A 27 - 358 Jmol OpenAstexViewer
B 27 - 358 Jmol OpenAstexViewer
C 27 - 358 Jmol OpenAstexViewer
D 27 - 358 Jmol OpenAstexViewer
6GPK A 27 - 358 Jmol OpenAstexViewer
B 27 - 358 Jmol OpenAstexViewer
C 27 - 358 Jmol OpenAstexViewer
D 27 - 358 Jmol OpenAstexViewer
6GPL B 27 - 358 Jmol OpenAstexViewer
C 27 - 358 Jmol OpenAstexViewer
D 27 - 358 Jmol OpenAstexViewer
E 27 - 358 Jmol OpenAstexViewer
6Q94 A 27 - 358 Jmol OpenAstexViewer
B 27 - 358 Jmol OpenAstexViewer
C 27 - 358 Jmol OpenAstexViewer
D 27 - 358 Jmol OpenAstexViewer
E 27 - 358 Jmol OpenAstexViewer
F 27 - 358 Jmol OpenAstexViewer
G 27 - 358 Jmol OpenAstexViewer
H 27 - 358 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.