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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: REV3L_HUMAN (O60673)

Summary

This is the summary of UniProt entry REV3L_HUMAN (O60673).

Description: DNA polymerase zeta catalytic subunit EC=2.7.7.7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 3130 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam DNA_pol_B_exo1 43 203
disorder n/a 193 195
disorder n/a 262 297
disorder n/a 302 303
disorder n/a 333 337
disorder n/a 342 343
disorder n/a 346 380
disorder n/a 387 407
disorder n/a 409 414
disorder n/a 416 469
disorder n/a 484 509
low_complexity n/a 494 511
disorder n/a 511 512
disorder n/a 520 548
disorder n/a 559 563
disorder n/a 590 615
disorder n/a 617 619
disorder n/a 621 622
disorder n/a 625 648
disorder n/a 671 682
disorder n/a 684 708
disorder n/a 713 728
disorder n/a 730 732
Pfam DUF4683 745 1133
disorder n/a 757 764
disorder n/a 771 787
disorder n/a 789 791
disorder n/a 815 885
low_complexity n/a 842 854
disorder n/a 929 933
disorder n/a 936 943
disorder n/a 947 964
low_complexity n/a 960 970
disorder n/a 1035 1091
low_complexity n/a 1043 1058
disorder n/a 1095 1098
disorder n/a 1114 1145
low_complexity n/a 1136 1148
disorder n/a 1147 1148
disorder n/a 1150 1231
low_complexity n/a 1188 1199
disorder n/a 1254 1255
disorder n/a 1265 1266
disorder n/a 1272 1283
disorder n/a 1310 1311
disorder n/a 1372 1382
disorder n/a 1440 1451
disorder n/a 1453 1458
disorder n/a 1482 1488
disorder n/a 1490 1518
disorder n/a 1520 1522
disorder n/a 1525 1600
coiled_coil n/a 1527 1547
disorder n/a 1609 1612
disorder n/a 1615 1620
disorder n/a 1644 1646
disorder n/a 1697 1705
disorder n/a 1708 1711
disorder n/a 1715 1716
disorder n/a 1728 1736
disorder n/a 1739 1750
disorder n/a 1774 1775
disorder n/a 1782 1786
disorder n/a 1793 1818
disorder n/a 1843 1883
low_complexity n/a 1849 1865
disorder n/a 1885 1896
disorder n/a 1905 1917
disorder n/a 1919 1926
disorder n/a 1955 1983
disorder n/a 2016 2120
low_complexity n/a 2038 2057
low_complexity n/a 2101 2127
disorder n/a 2124 2156
disorder n/a 2166 2186
disorder n/a 2215 2239
Pfam DNA_pol_B_exo1 2221 2484
disorder n/a 2241 2242
disorder n/a 2257 2270
Pfam DNA_pol_B 2549 3001
disorder n/a 3019 3025
disorder n/a 3027 3028
Pfam zf-C4pol 3042 3110
coiled_coil n/a 3065 3088
low_complexity n/a 3070 3082

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60673. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFSVRIVTAD YYMASPLQGL DTCQSPLTQA PVKKVPVVRV FGATPAGQKT
50
51
CLHLHGIFPY LYVPYDGYGQ QPESYLSQMA FSIDRALNVA LGNPSSTAQH
100
101
VFKVSLVSGM PFYGYHEKER HFMKIYLYNP TMVKRICELL QSGAIMNKFY
150
151
QPHEAHIPYL LQLFIDYNLY GMNLINLAAV KFRKARRKSN TLHATGSCKN
200
201
HLSGNSLADT LFRWEQDEIP SSLILEGVEP QSTCELEVDA VAADILNRLD
250
251
IEAQIGGNPG LQAIWEDEKQ RRRNRNETSQ MSQPESQDHR FVPATESEKK
300
301
FQKRLQEILK QNDFSVTLSG SVDYSDGSQE FSAELTLHSE VLSPEMLQCT
350
351
PANMVEVHKD KESSKGHTRH KVEEALINEE AILNLMENSQ TFQPLTQRLS
400
401
ESPVFMDSSP DEALVHLLAG LESDGYRGER NRMPSPCRSF GNNKYPQNSD
450
451
DEENEPQIEK EEMELSLVMS QRWDSNIEEH CAKKRSLCRN THRSSTEDDD
500
501
SSSGEEMEWS DNSLLLASLS IPQLDGTADE NSDNPLNNEN SRTHSSVIAT
550
551
SKLSVKPSIF HKDAATLEPS SSAKITFQCK HTSALSSHVL NKEDLIEDLS
600
601
QTNKNTEKGL DNSVTSFTNE STYSMKYPGS LSSTVHSENS HKENSKKEIL
650
651
PVSSCESSIF DYEEDIPSVT RQVPSRKYTN IRKIEKDSPF IHMHRHPNEN
700
701
TLGKNSFNFS DLNHSKNKVS SEGNEKGNST ALSSLFPSSF TENCELLSCS
750
751
GENRTMVHSL NSTADESGLN KLKIRYEEFQ EHKTEKPSLS QQAAHYMFFP
800
801
SVVLSNCLTR PQKLSPVTYK LQPGNKPSRL KLNKRKLAGH QETSTKSSET
850
851
GSTKDNFIQN NPCNSNPEKD NALASDLTKT TRGAFENKTP TDGFIDCHFG
900
901
DGTLETEQSF GLYGNKYTLR AKRKVNYETE DSESSFVTHN SKISLPHPME
950
951
IGESLDGTLK SRKRRKMSKK LPPVIIKYII INRFRGRKNM LVKLGKIDSK
1000
1001
EKQVILTEEK MELYKKLAPL KDFWPKVPDS PATKYPIYPL TPKKSHRRKS
1050
1051
KHKSAKKKTG KQQRTNNENI KRTLSFRKKR SHAILSPPSP SYNAETEDCD
1100
1101
LNYSDVMSKL GFLSERSTSP INSSPPRCWS PTDPRAEEIM AAAEKEAMLF
1150
1151
KGPNVYKKTV NSRIGKTSRA RAQIKKSKAK LANPSIVTKK RNKRNQTNKL
1200
1201
VDDGKKKPRA KQKTNEKGTS RKHTTLKDEK IKSQSGAEVK FVLKHQNVSE
1250
1251
FASSSGGSQL LFKQKDMPLM GSAVDHPLSA SLPTGINAQQ KLSGCFSSFL
1300
1301
ESKKSVDLQT FPSSRDDLHP SVVCNSIGPG VSKINVQRPH NQSAMFTLKE
1350
1351
STLIQKNIFD LSNHLSQVAQ NTQISSGMSS KIEDNANNIQ RNYLSSIGKL
1400
1401
SEYRNSLESK LDQAYTPNFL HCKDSQQQIV CIAEQSKHSE TCSPGNTASE
1450
1451
ESQMPNNCFV TSLRSPIKQI AWEQKQRGFI LDMSNFKPER VKPRSLSEAI
1500
1501
SQTKALSQCK NRNVSTPSAF GEGQSGLAVL KELLQKRQQK AQNANTTQDP
1550
1551
LSNKHQPNKN ISGSLEHNKA NKRTRSVTSP RKPRTPRSTK QKEKIPKLLK
1600
1601
VDSLNLQNSS QLDNSVSDDS PIFFSDPGFE SCYSLEDSLS PEHNYNFDIN
1650
1651
TIGQTGFCSF YSGSQFVPAD QNLPQKFLSD AVQDLFPGQA IEKNEFLSHD
1700
1701
NQKCDEDKHH TTDSASWIRS GTLSPEIFEK STIDSNENRR HNQWKNSFHP
1750
1751
LTTRSNSIMD SFCVQQAEDC LSEKSRLNRS SVSKEVFLSL PQPNNSDWIQ
1800
1801
GHTRKEMGQS LDSANTSFTA ILSSPDGELV DVACEDLELY VSRNNDMLTP
1850
1851
TPDSSPRSTS SPSQSKNGSF TPRTANILKP LMSPPSREEI MATLLDHDLS
1900
1901
ETIYQEPFCS NPSDVPEKPR EIGGRLLMVE TRLANDLAEF EGDFSLEGLR
1950
1951
LWKTAFSAMT QNPRPGSPLR SGQGVVNKGS SNSPKMVEDK KIVIMPCKCA
2000
2001
PSRQLVQVWL QAKEEYERSK KLPKTKPTGV VKSAENFSSS VNPDDKPVVP
2050
2051
PKMDVSPCIL PTTAHTKEDV DNSQIALQAP TTGCSQTASE SQMLPPVASA
2100
2101
SDPEKDEDDD DNYYISYSSP DSPVIPPWQQ PISPDSKALN GDDRPSSPVE
2150
2151
ELPSLAFENF LKPIKDGIQK SPCSEPQEPL VISPINTRAR TGKCESLCFH
2200
2201
STPIIQRKLL ERLPEAPGLS PLSTEPKTQK LSNKKGSNTD TLRRVLLTQA
2250
2251
KNQFAAVNTP QKETSQIDGP SLNNTYGFKV SIQNLQEAKA LHEIQNLTLI
2300
2301
SVELHARTRR DLEPDPEFDP ICALFYCISS DTPLPDTEKT ELTGVIVIDK
2350
2351
DKTVFSQDIR YQTPLLIRSG ITGLEVTYAA DEKALFHEIA NIIKRYDPDI
2400
2401
LLGYEIQMHS WGYLLQRAAA LSIDLCRMIS RVPDDKIENR FAAERDEYGS
2450
2451
YTMSEINIVG RITLNLWRIM RNEVALTNYT FENVSFHVLH QRFPLFTFRV
2500
2501
LSDWFDNKTD LYRWKMVDHY VSRVRGNLQM LEQLDLIGKT SEMARLFGIQ
2550
2551
FLHVLTRGSQ YRVESMMLRI AKPMNYIPVT PSVQQRSQMR APQCVPLIME
2600
2601
PESRFYSNSV LVLDFQSLYP SIVIAYNYCF STCLGHVENL GKYDEFKFGC
2650
2651
TSLRVPPDLL YQVRHDITVS PNGVAFVKPS VRKGVLPRML EEILKTRFMV
2700
2701
KQSMKAYKQD RALSRMLDAR QLGLKLIANV TFGYTSANFS GRMPCIEVGD
2750
2751
SIVHKARETL ERAIKLVNDT KKWGARVVYG DTDSMFVLLK GATKEQSFKI
2800
2801
GQEIAEAVTA TNPKPVKLKF EKVYLPCVLQ TKKRYVGYMY ETLDQKDPVF
2850
2851
DAKGIETVRR DSCPAVSKIL ERSLKLLFET RDISLIKQYV QRQCMKLLEG
2900
2901
KASIQDFIFA KEYRGSFSYK PGACVPALEL TRKMLTYDRR SEPQVGERVP
2950
2951
YVIIYGTPGV PLIQLVRRPV EVLQDPTLRL NATYYITKQI LPPLARIFSL
3000
3001
IGIDVFSWYH ELPRIHKATS SSRSEPEGRK GTISQYFTTL HCPVCDDLTQ
3050
3051
HGICSKCRSQ PQHVAVILNQ EIRELERQQE QLVKICKNCT GCFDRHIPCV
3100
3101
SLNCPVLFKL SRVNRELSKA PYLRQLLDQF                      
3130
 

Show the unformatted sequence.

Checksums:
CRC64:4FBAA214639DF3C6
MD5:6029f9723db4e6e414c97fc913b64442

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.