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96  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: JAK2_HUMAN (O60674)

Summary

This is the summary of UniProt entry JAK2_HUMAN (O60674).

Description: Tyrosine-protein kinase JAK2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1132 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 7 18
Pfam FERM_F1 39 134
Pfam FERM_F2 142 261
low_complexity n/a 223 242
Pfam Jak1_Phl 299 381
disorder n/a 301 302
disorder n/a 337 342
Pfam SH2 400 481
disorder n/a 522 525
Pfam PK_Tyr_Ser-Thr 545 805
Pfam PK_Tyr_Ser-Thr 849 1123

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60674. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS
50
51
EADYLTFPSG EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH
100
101
VFHIDESTRH NVLYRIRFYF PRWYCSGSNR AYRHGISRGA EAPLLDDFVM
150
151
SYLFAQWRHD FVHGWIKVPV THETQEECLG MAVLDMMRIA KENDQTPLAI
200
201
YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF SQCKATARNL
250
251
KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR
300
301
GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK
350
351
NLEIELSSLR EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIQSNC
400
401
HGPISMDFAI SKLKKAGNQT GLYVLRCSPK DFNKYFLTFA VERENVIEYK
450
451
HCLITKNENE EYNLSGTKKN FSSLKDLLNC YQMETVRSDN IIFQFTKCCP
500
501
PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI RNEDLIFNES
550
551
LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM
600
601
MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK
650
651
LEVAKQLAWA MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP
700
701
GISITVLPKD ILQERIPWVP PECIENPKNL NLATDKWSFG TTLWEICSGG
750
751
DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL ANLINNCMDY EPDFRPSFRA
800
801
IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD PTQFEERHLK
850
851
FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
900
901
ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH
950
951
IKLLQYTSQI CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV
1000
1001
LPQDKEYYKV KEPGESPIFW YAPESLTESK FSVASDVWSF GVVLYELFTY
1050
1051
IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE LLKNNGRLPR PDGCPDEIYM
1100
1101
IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG                   
1132
 

Show the unformatted sequence.

Checksums:
CRC64:C30669EF1A7DA80C
MD5:06a47ffcc300b3340ae364cbdaf040be

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FERM_F1 39 - 134 4Z32 A 39 - 134 Show 3D Structure View in InterPro
B 39 - 134 Show 3D Structure View in InterPro
C 39 - 134 Show 3D Structure View in InterPro
D 39 - 134 Show 3D Structure View in InterPro
E 39 - 134 Show 3D Structure View in InterPro
F 39 - 134 Show 3D Structure View in InterPro
G 39 - 134 Show 3D Structure View in InterPro
H 39 - 134 Show 3D Structure View in InterPro
6E2P A 39 - 134 Show 3D Structure View in InterPro
6E2Q A 39 - 134 Show 3D Structure View in InterPro
B 39 - 134 Show 3D Structure View in InterPro
C 39 - 134 Show 3D Structure View in InterPro
D 39 - 134 Show 3D Structure View in InterPro
41 - 134 6E2P B 41 - 134 Show 3D Structure View in InterPro
FERM_F2 142 - 261 4Z32 A 142 - 261 Show 3D Structure View in InterPro
B 142 - 261 Show 3D Structure View in InterPro
C 142 - 261 Show 3D Structure View in InterPro
D 142 - 261 Show 3D Structure View in InterPro
E 142 - 261 Show 3D Structure View in InterPro
F 142 - 261 Show 3D Structure View in InterPro
G 142 - 261 Show 3D Structure View in InterPro
H 142 - 261 Show 3D Structure View in InterPro
6E2P A 142 - 261 Show 3D Structure View in InterPro
B 142 - 261 Show 3D Structure View in InterPro
6E2Q A 142 - 261 Show 3D Structure View in InterPro
B 142 - 261 Show 3D Structure View in InterPro
C 142 - 261 Show 3D Structure View in InterPro
D 142 - 261 Show 3D Structure View in InterPro
Jak1_Phl 299 - 381 4Z32 A 299 - 381 Show 3D Structure View in InterPro
B 299 - 381 Show 3D Structure View in InterPro
C 299 - 381 Show 3D Structure View in InterPro
D 299 - 381 Show 3D Structure View in InterPro
E 299 - 381 Show 3D Structure View in InterPro
F 299 - 381 Show 3D Structure View in InterPro
G 299 - 381 Show 3D Structure View in InterPro
H 299 - 381 Show 3D Structure View in InterPro
6E2P A 299 - 381 Show 3D Structure View in InterPro
B 299 - 381 Show 3D Structure View in InterPro
6E2Q A 299 - 381 Show 3D Structure View in InterPro
B 299 - 381 Show 3D Structure View in InterPro
C 299 - 381 Show 3D Structure View in InterPro
D 299 - 381 Show 3D Structure View in InterPro
PK_Tyr_Ser-Thr 545 - 805 4FVP A 545 - 805 Show 3D Structure View in InterPro
4FVQ A 545 - 805 Show 3D Structure View in InterPro
4FVR A 545 - 805 Show 3D Structure View in InterPro
5I4N A 545 - 805 Show 3D Structure View in InterPro
5USZ A 545 - 805 Show 3D Structure View in InterPro
5UT0 A 545 - 805 Show 3D Structure View in InterPro
5UT1 A 545 - 805 Show 3D Structure View in InterPro
5UT2 A 545 - 805 Show 3D Structure View in InterPro
5UT3 A 545 - 805 Show 3D Structure View in InterPro
5UT4 A 545 - 805 Show 3D Structure View in InterPro
5UT5 A 545 - 805 Show 3D Structure View in InterPro
5UT6 A 545 - 805 Show 3D Structure View in InterPro
5WIJ A 545 - 805 Show 3D Structure View in InterPro
5WIK B 545 - 805 Show 3D Structure View in InterPro
5WIL A 545 - 805 Show 3D Structure View in InterPro
5WIM A 545 - 805 Show 3D Structure View in InterPro
5WIN A 545 - 805 Show 3D Structure View in InterPro
6BRW A 545 - 805 Show 3D Structure View in InterPro
6BS0 A 545 - 805 Show 3D Structure View in InterPro
6BSS A 545 - 805 Show 3D Structure View in InterPro
6D2I A 545 - 805 Show 3D Structure View in InterPro
B 545 - 805 Show 3D Structure View in InterPro
6G3C A 545 - 805 Show 3D Structure View in InterPro
B 545 - 805 Show 3D Structure View in InterPro
6M9H A 545 - 805 Show 3D Structure View in InterPro
6OAV A 545 - 805 Show 3D Structure View in InterPro
6OBB A 545 - 805 Show 3D Structure View in InterPro
6OBF A 545 - 805 Show 3D Structure View in InterPro
6OBL A 545 - 805 Show 3D Structure View in InterPro
6OCC A 545 - 805 Show 3D Structure View in InterPro
6XJK A 545 - 805 Show 3D Structure View in InterPro
849 - 1123 2B7A A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
2W1I A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
2XA4 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
3E62 A 849 - 1123 Show 3D Structure View in InterPro
3E63 A 849 - 1123 Show 3D Structure View in InterPro
3E64 A 849 - 1123 Show 3D Structure View in InterPro
3FUP A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
3IO7 A 849 - 1123 Show 3D Structure View in InterPro
3IOK A 849 - 1123 Show 3D Structure View in InterPro
3JY9 A 849 - 1123 Show 3D Structure View in InterPro
3KCK A 849 - 1123 Show 3D Structure View in InterPro
3KRR A 849 - 1123 Show 3D Structure View in InterPro
3LPB A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
3Q32 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
3RVG A 849 - 1123 Show 3D Structure View in InterPro
3TJC A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
3TJD A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
3UGC A 849 - 1123 Show 3D Structure View in InterPro
3ZMM A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4AQC A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4BBE A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
C 849 - 1123 Show 3D Structure View in InterPro
D 849 - 1123 Show 3D Structure View in InterPro
4BBF A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
C 849 - 1123 Show 3D Structure View in InterPro
D 849 - 1123 Show 3D Structure View in InterPro
4C61 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4C62 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4D0W A 849 - 1123 Show 3D Structure View in InterPro
4D0X A 849 - 1123 Show 3D Structure View in InterPro
4D1S A 849 - 1123 Show 3D Structure View in InterPro
4E4M A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
D 849 - 1123 Show 3D Structure View in InterPro
E 849 - 1123 Show 3D Structure View in InterPro
4E6D A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4E6Q A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4F08 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4F09 A 849 - 1123 Show 3D Structure View in InterPro
4GFM A 849 - 1123 Show 3D Structure View in InterPro
4GMY A 849 - 1123 Show 3D Structure View in InterPro
4HGE A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4IVA A 849 - 1123 Show 3D Structure View in InterPro
4JI9 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4JIA A 849 - 1123 Show 3D Structure View in InterPro
4P7E A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
4YTC A 849 - 1123 Show 3D Structure View in InterPro
4YTF A 849 - 1123 Show 3D Structure View in InterPro
4YTH A 849 - 1123 Show 3D Structure View in InterPro
4YTI A 849 - 1123 Show 3D Structure View in InterPro
4ZIM A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5AEP A 849 - 1123 Show 3D Structure View in InterPro
5CF4 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5CF5 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5CF6 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5CF8 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5HEZ A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
C 849 - 1123 Show 3D Structure View in InterPro
D 849 - 1123 Show 3D Structure View in InterPro
5L3A A 849 - 1123 Show 3D Structure View in InterPro
5TQ3 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5TQ4 A 849 - 1123 Show 3D Structure View in InterPro
5TQ5 A 849 - 1123 Show 3D Structure View in InterPro
5TQ6 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5TQ7 A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5TQ8 A 849 - 1123 Show 3D Structure View in InterPro
5USY A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
5WEV A 849 - 1123 Show 3D Structure View in InterPro
6AAJ A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
6BBV A 849 - 1123 Show 3D Structure View in InterPro
6DRW A 849 - 1123 Show 3D Structure View in InterPro
6TPD A 849 - 1123 Show 3D Structure View in InterPro
6X8E A 849 - 1123 Show 3D Structure View in InterPro
B 849 - 1123 Show 3D Structure View in InterPro
SH2 400 - 480 4Z32 H 400 - 480 Show 3D Structure View in InterPro
400 - 481 4Z32 A 400 - 481 Show 3D Structure View in InterPro
B 400 - 481 Show 3D Structure View in InterPro
C 400 - 481 Show 3D Structure View in InterPro
D 400 - 481 Show 3D Structure View in InterPro
E 400 - 481 Show 3D Structure View in InterPro
F 400 - 481 Show 3D Structure View in InterPro
G 400 - 481 Show 3D Structure View in InterPro
6E2P A 400 - 481 Show 3D Structure View in InterPro
B 400 - 481 Show 3D Structure View in InterPro
6E2Q A 400 - 481 Show 3D Structure View in InterPro
B 400 - 481 Show 3D Structure View in InterPro
C 400 - 481 Show 3D Structure View in InterPro
D 400 - 481 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;