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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: UGDH_HUMAN (O60701)

Summary

This is the summary of UniProt entry UGDH_HUMAN (O60701).

Description: UDP-glucose 6-dehydrogenase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 494 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam UDPG_MGDP_dh_N 5 195
disorder n/a 179 183
Pfam UDPG_MGDP_dh 214 309
Pfam UDPG_MGDP_dh_C 332 447
disorder n/a 478 494

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60701. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFEIKKICCI GAGYVGGPTC SVIAHMCPEI RVTVVDVNES RINAWNSPTL
50
51
PIYEPGLKEV VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK
100
101
GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP
150
151
NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDETPEGQR AVQALCAVYE
200
201
HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CEATGADVEE
250
251
VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
300
301
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS
350
351
IYISKYLMDE GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD
400
401
PYEACDGAHA VVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDGLHN
450
451
ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP KFSLQDPPNK KPKV      
494
 

Show the unformatted sequence.

Checksums:
CRC64:9C9DA5E1227D65CC
MD5:1ab228ec404807ff7a3f0c4d7a722716

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
UDPG_MGDP_dh 214 - 309 2Q3E A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
G 214 - 309 Show 3D Structure View in InterPro
H 214 - 309 Show 3D Structure View in InterPro
I 214 - 309 Show 3D Structure View in InterPro
J 214 - 309 Show 3D Structure View in InterPro
K 214 - 309 Show 3D Structure View in InterPro
L 214 - 309 Show 3D Structure View in InterPro
2QG4 A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
G 214 - 309 Show 3D Structure View in InterPro
H 214 - 309 Show 3D Structure View in InterPro
3ITK A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
3KHU A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
3PRJ A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
3PTZ A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
3TDK A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
G 214 - 309 Show 3D Structure View in InterPro
H 214 - 309 Show 3D Structure View in InterPro
I 214 - 309 Show 3D Structure View in InterPro
J 214 - 309 Show 3D Structure View in InterPro
K 214 - 309 Show 3D Structure View in InterPro
L 214 - 309 Show 3D Structure View in InterPro
3TF5 A 213 - 308 Show 3D Structure View in InterPro
B 213 - 308 Show 3D Structure View in InterPro
C 213 - 308 Show 3D Structure View in InterPro
4EDF A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
4RJT A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
5TJH A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
5VR8 A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
5W4X A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
6C4J A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
G 214 - 309 Show 3D Structure View in InterPro
H 214 - 309 Show 3D Structure View in InterPro
I 214 - 309 Show 3D Structure View in InterPro
J 214 - 309 Show 3D Structure View in InterPro
K 214 - 309 Show 3D Structure View in InterPro
L 214 - 309 Show 3D Structure View in InterPro
6C4K A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
6C58 A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
6C5A A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
6C5Z A 214 - 309 Show 3D Structure View in InterPro
B 214 - 309 Show 3D Structure View in InterPro
C 214 - 309 Show 3D Structure View in InterPro
D 214 - 309 Show 3D Structure View in InterPro
E 214 - 309 Show 3D Structure View in InterPro
F 214 - 309 Show 3D Structure View in InterPro
UDPG_MGDP_dh_C 332 - 447 2Q3E A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
G 332 - 447 Show 3D Structure View in InterPro
H 332 - 447 Show 3D Structure View in InterPro
I 332 - 447 Show 3D Structure View in InterPro
J 332 - 447 Show 3D Structure View in InterPro
K 332 - 447 Show 3D Structure View in InterPro
L 332 - 447 Show 3D Structure View in InterPro
2QG4 A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
G 332 - 447 Show 3D Structure View in InterPro
H 332 - 447 Show 3D Structure View in InterPro
3ITK A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
3KHU A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
3PRJ A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
3PTZ A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
3TDK A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
G 332 - 447 Show 3D Structure View in InterPro
H 332 - 447 Show 3D Structure View in InterPro
I 332 - 447 Show 3D Structure View in InterPro
J 332 - 447 Show 3D Structure View in InterPro
K 332 - 447 Show 3D Structure View in InterPro
L 332 - 447 Show 3D Structure View in InterPro
3TF5 A 331 - 446 Show 3D Structure View in InterPro
B 331 - 446 Show 3D Structure View in InterPro
C 331 - 446 Show 3D Structure View in InterPro
4EDF A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
4RJT A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
5TJH A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
5VR8 A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
5W4X A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
6C4J A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
G 332 - 447 Show 3D Structure View in InterPro
H 332 - 447 Show 3D Structure View in InterPro
I 332 - 447 Show 3D Structure View in InterPro
J 332 - 447 Show 3D Structure View in InterPro
K 332 - 447 Show 3D Structure View in InterPro
L 332 - 447 Show 3D Structure View in InterPro
6C4K A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
6C58 A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
6C5A A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
6C5Z A 332 - 447 Show 3D Structure View in InterPro
B 332 - 447 Show 3D Structure View in InterPro
C 332 - 447 Show 3D Structure View in InterPro
D 332 - 447 Show 3D Structure View in InterPro
E 332 - 447 Show 3D Structure View in InterPro
F 332 - 447 Show 3D Structure View in InterPro
UDPG_MGDP_dh_N 103 - 195 6C5Z B 103 - 195 Show 3D Structure View in InterPro
5 - 195 2Q3E A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
G 5 - 195 Show 3D Structure View in InterPro
H 5 - 195 Show 3D Structure View in InterPro
I 5 - 195 Show 3D Structure View in InterPro
J 5 - 195 Show 3D Structure View in InterPro
K 5 - 195 Show 3D Structure View in InterPro
L 5 - 195 Show 3D Structure View in InterPro
2QG4 A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
G 5 - 195 Show 3D Structure View in InterPro
H 5 - 195 Show 3D Structure View in InterPro
3ITK A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
3KHU A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
3PRJ A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
3PTZ A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
3TDK A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
G 5 - 195 Show 3D Structure View in InterPro
H 5 - 195 Show 3D Structure View in InterPro
I 5 - 195 Show 3D Structure View in InterPro
J 5 - 195 Show 3D Structure View in InterPro
K 5 - 195 Show 3D Structure View in InterPro
L 5 - 195 Show 3D Structure View in InterPro
3TF5 A 5 - 194 Show 3D Structure View in InterPro
B 5 - 194 Show 3D Structure View in InterPro
C 5 - 194 Show 3D Structure View in InterPro
4EDF A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
4RJT A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
5TJH A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
5VR8 A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
5W4X A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
6C4J A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
G 5 - 195 Show 3D Structure View in InterPro
H 5 - 195 Show 3D Structure View in InterPro
I 5 - 195 Show 3D Structure View in InterPro
J 5 - 195 Show 3D Structure View in InterPro
K 5 - 195 Show 3D Structure View in InterPro
L 5 - 195 Show 3D Structure View in InterPro
6C4K A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
6C58 A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
6C5A A 5 - 195 Show 3D Structure View in InterPro
B 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
6C5Z A 5 - 195 Show 3D Structure View in InterPro
C 5 - 195 Show 3D Structure View in InterPro
D 5 - 195 Show 3D Structure View in InterPro
E 5 - 195 Show 3D Structure View in InterPro
F 5 - 195 Show 3D Structure View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;