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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KIN17_HUMAN (O60870)

Summary

This is the summary of UniProt entry KIN17_HUMAN (O60870).

Description: DNA/RNA-binding protein KIN17
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 393 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Kin17_mid 52 177
disorder n/a 152 160
low_complexity n/a 152 168
coiled_coil n/a 156 176
disorder n/a 164 169
disorder n/a 174 179
disorder n/a 183 195
disorder n/a 205 209
low_complexity n/a 208 224
disorder n/a 216 268
low_complexity n/a 240 259
coiled_coil n/a 250 277
Pfam KN17_SH3 276 328

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60870. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGKSDFLTPK AIANRIKSKG LQKLRWYCQM CQKQCRDENG FKCHCMSESH
50
51
QRQLLLASEN PQQFMDYFSE EFRNDFLELL RRRFGTKRVH NNIVYNEYIS
100
101
HREHIHMNAT QWETLTDFTK WLGREGLCKV DETPKGWYIQ YIDRDPETIR
150
151
RQLELEKKKK QDLDDEEKTA KFIEEQVRRG LEGKEQEVPT FTELSRENDE
200
201
EKVTFNLSKG ACSSSGATSS KSSTLGPSAL KTIGSSASVK RKESSQSSTQ
250
251
SKEKKKKKSA LDEIMEIEEE KKRTARTDYW LQPEIIVKII TKKLGEKYHK
300
301
KKAIVKEVID KYTAVVKMID SGDKLKLDQT HLETVIPAPG KRILVLNGGY
350
351
RGNEGTLESI NEKTFSATIV IETGPLKGRR VEGIQYEDIS KLA       
393
 

Show the unformatted sequence.

Checksums:
CRC64:515A89B4C8A4C007
MD5:196dd9f4e702e70712db3468b3c162ee

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Kin17_mid 147 - 177 7ABH 7 147 - 177 Show 3D Structure View in InterPro
52 - 160 2V1N A 3 - 111 Show 3D Structure View in InterPro
60 - 177 7ABI 7 60 - 177 Show 3D Structure View in InterPro
KN17_SH3 276 - 328 2CKK A 10 - 62 Show 3D Structure View in InterPro
7ABI 7 276 - 328 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;