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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RAMP1_HUMAN (O60894)

Summary

This is the summary of UniProt entry RAMP1_HUMAN (O60894).

Description: Receptor activity-modifying protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 148 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 27
Pfam RAMP 37 146
transmembrane n/a 118 139
low_complexity n/a 123 137

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O60894. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MARALCRLPR RGLWLLLAHH LFMTTACQEA NYGALLRELC LTQFQVDMEA
50
51
VGETLWCDWG RTIRSYRELA DCTWHMAEKL GCFWPNAEVD RFFLAVHGRY
100
101
FRSCPISGRA VRDPPGSILY PFIVVPITVT LLVTALVVWQ SKRTEGIV  
148
 

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Checksums:
CRC64:8530DD590BAEBE5C
MD5:7bc2146037af829e6e3df6782efbc86a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RAMP 37 - 105 3N7P E 37 - 105 Jmol OpenAstexViewer
F 37 - 105 Jmol OpenAstexViewer
5V6Y A 1037 - 1105 Jmol OpenAstexViewer
37 - 106 3N7R D 37 - 106 Jmol OpenAstexViewer
5V6Y B 1037 - 1106 Jmol OpenAstexViewer
C 1037 - 1106 Jmol OpenAstexViewer
D 1037 - 1106 Jmol OpenAstexViewer
37 - 107 2YX8 A 37 - 107 Jmol OpenAstexViewer
3N7R C 37 - 107 Jmol OpenAstexViewer
37 - 108 4RWG A 1037 - 1108 Jmol OpenAstexViewer
B 1037 - 1108 Jmol OpenAstexViewer
C 1037 - 1108 Jmol OpenAstexViewer
37 - 109 6D1U C 1037 - 1109 Jmol OpenAstexViewer
37 - 110 3N7S D 37 - 110 Jmol OpenAstexViewer
6D1U B 1037 - 1110 Jmol OpenAstexViewer
37 - 111 6D1U A 1037 - 1111 Jmol OpenAstexViewer
37 - 116 3N7P D 37 - 116 Jmol OpenAstexViewer
3N7S C 37 - 116 Jmol OpenAstexViewer
37 - 117 3N7P R 37 - 117 Jmol OpenAstexViewer
37 - 143 6E3Y E 37 - 143 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.