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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SOCS5_HUMAN (O75159)

Summary

This is the summary of UniProt entry SOCS5_HUMAN (O75159).

Description: Suppressor of cytokine signaling 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 536 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 24 27
disorder n/a 29 35
disorder n/a 41 89
disorder n/a 101 165
Pfam SOCS 145 197
low_complexity n/a 158 169
disorder n/a 167 176
disorder n/a 200 201
disorder n/a 231 234
disorder n/a 249 252
disorder n/a 257 287
low_complexity n/a 258 270
disorder n/a 308 323
disorder n/a 327 331
disorder n/a 333 339
disorder n/a 342 351
Pfam SH2 381 459
Pfam SOCS_box 480 515

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75159. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS
50
51
TPQQQSSPLR ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS
100
101
CVTPGTRLAR RDSYSRHAPW GGKKKHSCST KTQSSLDADK KFGRTRSGLQ
150
151
RRERRYGVSS VHDMDSVSSR TVGSRSLRQR LQDTVGLCFP MRTYSKQSKP
200
201
LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV SPHSTFFDTF
250
251
DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
300
301
PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH
350
351
VSRQGAWKVH TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE
400
401
GTFLLRDSAQ EDYLFSVSFR RYNRSLHARI EQWNHNFSFD AHDPCVFHSS
450
451
TVTGLLEHYK DPSSCMFFEP LLTISLNRTF PFSLQYICRA VICRCTTYDG
500
501
IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK               
536
 

Show the unformatted sequence.

Checksums:
CRC64:0629CDCF2A97E9D8
MD5:bee0da9fb5a08e3d8b774fa3da01a9fd

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;