Summary
This is the summary of UniProt entry SOCS5_HUMAN (O75159).
| Description: | Suppressor of cytokine signaling 5 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 536 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 24 | 27 |
| disorder | n/a | 29 | 35 |
| disorder | n/a | 41 | 89 |
| disorder | n/a | 101 | 165 |
| Pfam | SOCS | 145 | 197 |
| low_complexity | n/a | 158 | 169 |
| disorder | n/a | 167 | 176 |
| disorder | n/a | 200 | 201 |
| disorder | n/a | 231 | 234 |
| disorder | n/a | 249 | 252 |
| disorder | n/a | 257 | 287 |
| low_complexity | n/a | 258 | 270 |
| disorder | n/a | 308 | 323 |
| disorder | n/a | 327 | 331 |
| disorder | n/a | 333 | 339 |
| disorder | n/a | 342 | 351 |
| Pfam | SH2 | 381 | 459 |
| Pfam | SOCS_box | 480 | 515 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O75159. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS
50 51
TPQQQSSPLR ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS
100 101
CVTPGTRLAR RDSYSRHAPW GGKKKHSCST KTQSSLDADK KFGRTRSGLQ
150 151
RRERRYGVSS VHDMDSVSSR TVGSRSLRQR LQDTVGLCFP MRTYSKQSKP
200 201
LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV SPHSTFFDTF
250 251
DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
300 301
PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH
350 351
VSRQGAWKVH TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE
400 401
GTFLLRDSAQ EDYLFSVSFR RYNRSLHARI EQWNHNFSFD AHDPCVFHSS
450 451
TVTGLLEHYK DPSSCMFFEP LLTISLNRTF PFSLQYICRA VICRCTTYDG
500 501
IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK
536
Show the unformatted sequence. |
| Checksums: |
CRC64:0629CDCF2A97E9D8
MD5:bee0da9fb5a08e3d8b774fa3da01a9fd
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
