Summary
This is the summary of UniProt entry CNOT3_HUMAN (O75175).
Description: | CCR4-NOT transcription complex subunit 3 |
Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
Length: | 753 amino acids |
Reference Proteome: |
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Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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Source | Domain | Start | End |
---|---|---|---|
Pfam | Not3 | 3 | 232 |
coiled_coil | n/a | 38 | 61 |
disorder | n/a | 105 | 112 |
disorder | n/a | 114 | 115 |
coiled_coil | n/a | 132 | 152 |
disorder | n/a | 150 | 169 |
low_complexity | n/a | 154 | 163 |
disorder | n/a | 210 | 214 |
disorder | n/a | 220 | 227 |
disorder | n/a | 230 | 587 |
low_complexity | n/a | 256 | 273 |
low_complexity | n/a | 315 | 337 |
low_complexity | n/a | 343 | 361 |
low_complexity | n/a | 367 | 379 |
low_complexity | n/a | 395 | 420 |
low_complexity | n/a | 440 | 455 |
low_complexity | n/a | 455 | 466 |
low_complexity | n/a | 471 | 494 |
low_complexity | n/a | 489 | 510 |
low_complexity | n/a | 571 | 588 |
disorder | n/a | 618 | 626 |
Pfam | NOT2_3_5 | 620 | 747 |
disorder | n/a | 633 | 654 |
low_complexity | n/a | 641 | 655 |
low_complexity | n/a | 681 | 693 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O75175. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
Sequence: | 1
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK
50 51
EIKKLQRLRD QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT
100 101
KAYSKEGLGL AQKVDPAQKE KEEVGQWLTN TIDTLNMQVD QFESEVESLS
150 151
VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV RMLETILRML DNDSILVDAI
200 201
RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA TSPPSHSHME
250 251
DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP
300 301
AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP
350 351
SALGPKASPA PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG
400 401
GGSGGGGSSS SSNSSAGGGA GKQNGATSYS SVVADSPAEV ALSSSGGNNA
450 451
SSQALGPPSG PHNPPPSTSK EPSAAAPTGA GGVAPGSGNN SGGPSLLVPL
500 501
PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL SSLKSMAERA
550 551
AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC
600 601
PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH
650 651
QMPPPHSDTV EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT
700 701
KYMMWFQRHE EPKTITDEFE QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR
750 751
DLQ
753
Show the unformatted sequence. |
Checksums: |
CRC64:C9D4F8B9FEF6CD90
MD5:6f8430940eda9ceb571bc071a777cd65
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
---|---|---|---|---|---|
NOT2_3_5 | 620 - 747 | 4C0D | C | 620 - 747 | Jmol OpenAstexViewer |
5FU6 | C | 620 - 747 | Jmol OpenAstexViewer | ||
F | 620 - 747 | Jmol OpenAstexViewer | |||
5FU7 | C | 620 - 747 | Jmol OpenAstexViewer | ||
G | 620 - 747 | Jmol OpenAstexViewer | |||
656 - 747 | 4C0G | B | 656 - 747 | Jmol OpenAstexViewer | |
C | 656 - 747 | Jmol OpenAstexViewer | |||
D | 656 - 747 | Jmol OpenAstexViewer | |||
658 - 747 | 4C0G | E | 658 - 747 | Jmol OpenAstexViewer | |
F | 658 - 747 | Jmol OpenAstexViewer | |||
659 - 747 | 4C0G | A | 659 - 747 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.