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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CNOT3_HUMAN (O75175)

Summary

This is the summary of UniProt entry CNOT3_HUMAN (O75175).

Description: CCR4-NOT transcription complex subunit 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 753 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Not3 3 232
coiled_coil n/a 38 61
disorder n/a 105 112
disorder n/a 114 115
coiled_coil n/a 132 152
disorder n/a 150 169
low_complexity n/a 154 163
disorder n/a 210 214
disorder n/a 220 227
disorder n/a 230 587
low_complexity n/a 256 273
low_complexity n/a 315 337
low_complexity n/a 343 361
low_complexity n/a 367 379
low_complexity n/a 395 420
low_complexity n/a 440 455
low_complexity n/a 455 466
low_complexity n/a 471 494
low_complexity n/a 489 510
low_complexity n/a 571 588
disorder n/a 618 626
Pfam NOT2_3_5 620 747
disorder n/a 633 654
low_complexity n/a 641 655
low_complexity n/a 681 693

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75175. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK
50
51
EIKKLQRLRD QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT
100
101
KAYSKEGLGL AQKVDPAQKE KEEVGQWLTN TIDTLNMQVD QFESEVESLS
150
151
VQTRKKKGDK DKQDRIEGLK RHIEKHRYHV RMLETILRML DNDSILVDAI
200
201
RKIKDDVEYY VDSSQDPDFE ENEFLYDDLD LEDIPQALVA TSPPSHSHME
250
251
DEIFNQSSST PTSTTSSSPI PPSPANCTTE NSEDDKKRGR STDSEVSQSP
300
301
AKNGSKPVHS NQHPQSPAVP PTYPSGPPPA ASALSTTPGN NGVPAPAAPP
350
351
SALGPKASPA PSHNSGTPAP YAQAVAPPAP SGPSTTQPRP PSVQPSGGGG
400
401
GGSGGGGSSS SSNSSAGGGA GKQNGATSYS SVVADSPAEV ALSSSGGNNA
450
451
SSQALGPPSG PHNPPPSTSK EPSAAAPTGA GGVAPGSGNN SGGPSLLVPL
500
501
PVNPPSSPTP SFSDAKAAGA LLNGPPQFST APEIKAPEPL SSLKSMAERA
550
551
AISSGIEDPV PTLHLTERDI ILSSTSAPPA SAQPPLQLSE VNIPLSLGVC
600
601
PLGPVPLTKE QLYQQAMEEA AWHHMPHPSD SERIRQYLPR NPCPTPPYHH
650
651
QMPPPHSDTV EFYQRLSTET LFFIFYYLEG TKAQYLAAKA LKKQSWRFHT
700
701
KYMMWFQRHE EPKTITDEFE QGTYIYFDYE KWGQRKKEGF TFEYRYLEDR
750
751
DLQ                                                   
753
 

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Checksums:
CRC64:C9D4F8B9FEF6CD90
MD5:6f8430940eda9ceb571bc071a777cd65

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NOT2_3_5 620 - 747 4C0D C 620 - 747 Jmol OpenAstexViewer
5FU6 C 620 - 747 Jmol OpenAstexViewer
F 620 - 747 Jmol OpenAstexViewer
5FU7 C 620 - 747 Jmol OpenAstexViewer
G 620 - 747 Jmol OpenAstexViewer
656 - 747 4C0G B 656 - 747 Jmol OpenAstexViewer
C 656 - 747 Jmol OpenAstexViewer
D 656 - 747 Jmol OpenAstexViewer
658 - 747 4C0G E 658 - 747 Jmol OpenAstexViewer
F 658 - 747 Jmol OpenAstexViewer
659 - 747 4C0G A 659 - 747 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.