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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SEM7A_HUMAN (O75326)

Summary

This is the summary of UniProt entry SEM7A_HUMAN (O75326).

Description: Semaphorin-7A
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 666 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 21
sig_p n/a 1 44
low_complexity n/a 2 23
low_complexity n/a 18 41
disorder n/a 73 75
Pfam Sema 77 472
disorder n/a 254 259
disorder n/a 357 375
disorder n/a 377 382
disorder n/a 384 385
disorder n/a 389 390
Pfam PSI 492 550
disorder n/a 533 550
Pfam Ig_2 545 628
transmembrane n/a 640 665
low_complexity n/a 650 664

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75326. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS
50
51
GPRIFAVWKG HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF
100
101
PEGKNASVRT VNIGSTKGSC LDKRDCENYI TLLERRSEGL LACGTNARHP
150
151
SCWNLVNGTV VPLGEMRGYA PFSPDENSLV LFEGDEVYST IRKQEYNGKI
200
201
PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI YYFFREDNPD
250
251
KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF
300
301
NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS
350
351
LKGYHSSLPN PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP
400
401
LFHSKYHYQK VAVHRMQASH GETFHVLYLT TDRGTIHKVV EPGEQEHSFA
450
451
FNIMEIQPFR RAAAIQTMSL DAERRKLYVS SQWEVSQVPL DLCEVYGGGC
500
501
HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE CPNPKPDKAP
550
551
LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI
600
601
ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS
650
651
LWLGVLPTLT LGLLVH                                     
666
 

Show the unformatted sequence.

Checksums:
CRC64:AD3ABE56B5EBE194
MD5:239e228b6aaa8886d438aa7cdc5ba659

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ig_2 545 - 628 3NVQ A 545 - 628 Jmol OpenAstexViewer
E 545 - 628 Jmol OpenAstexViewer
PSI 492 - 550 3NVQ A 492 - 550 Jmol OpenAstexViewer
E 492 - 550 Jmol OpenAstexViewer
Sema 77 - 472 3NVQ A 77 - 472 Jmol OpenAstexViewer
E 77 - 472 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.