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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ULK1_HUMAN (O75385)

Summary

This is the summary of UniProt entry ULK1_HUMAN (O75385).

Description: Serine/threonine-protein kinase ULK1 EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1050 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
Pfam Pkinase 16 278
low_complexity n/a 58 70
disorder n/a 146 147
disorder n/a 243 244
low_complexity n/a 250 260
low_complexity n/a 280 316
disorder n/a 283 360
low_complexity n/a 339 355
disorder n/a 362 635
low_complexity n/a 398 424
low_complexity n/a 582 592
disorder n/a 638 640
disorder n/a 642 695
disorder n/a 701 811
low_complexity n/a 756 768
low_complexity n/a 774 785
disorder n/a 822 824
disorder n/a 826 838
Pfam DUF3543 853 1048

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75385. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEPGRGGTET VGKFEFSRKD LIGHGAFAVV FKGRHREKHD LEVAVKCINK
50
51
KNLAKSQTLL GKEIKILKEL KHENIVALYD FQEMANSVYL VMEYCNGGDL
100
101
ADYLHAMRTL SEDTIRLFLQ QIAGAMRLLH SKGIIHRDLK PQNILLSNPA
150
151
GRRANPNSIR VKIADFGFAR YLQSNMMAAT LCGSPMYMAP EVIMSQHYDG
200
201
KADLWSIGTI VYQCLTGKAP FQASSPQDLR LFYEKNKTLV PTIPRETSAP
250
251
LRQLLLALLQ RNHKDRMDFD EFFHHPFLDA SPSVRKSPPV PVPSYPSSGS
300
301
GSSSSSSSTS HLASPPSLGE MQQLQKTLAS PADTAGFLHS SRDSGGSKDS
350
351
SCDTDDFVMV PAQFPGDLVA EAPSAKPPPD SLMCSGSSLV ASAGLESHGR
400
401
TPSPSPPCSS SPSPSGRAGP FSSSRCGASV PIPVPTQVQN YQRIERNLQS
450
451
PTQFQTPRSS AIRRSGSTSP LGFARASPSP PAHAEHGGVL ARKMSLGGGR
500
501
PYTPSPQVGT IPERPGWSGT PSPQGAEMRG GRSPRPGSSA PEHSPRTSGL
550
551
GCRLHSAPNL SDLHVVRPKL PKPPTDPLGA VFSPPQASPP QPSHGLQSCR
600
601
NLRGSPKLPD FLQRNPLPPI LGSPTKAVPS FDFPKTPSSQ NLLALLARQG
650
651
VVMTPPRNRT LPDLSEVGPF HGQPLGPGLR PGEDPKGPFG RSFSTSRLTD
700
701
LLLKAAFGTQ APDPGSTESL QEKPMEIAPS AGFGGSLHPG ARAGGTSSPS
750
751
PVVFTVGSPP SGSTPPQGPR TRMFSAGPTG SASSSARHLV PGPCSEAPAP
800
801
ELPAPGHGCS FADPITANLE GAVTFEAPDL PEETLMEQEH TEILRGLRFT
850
851
LLFVQHVLEI AALKGSASEA AGGPEYQLQE SVVADQISLL SREWGFAEQL
900
901
VLYLKVAELL SSGLQSAIDQ IRAGKLCLSS TVKQVVRRLN ELYKASVVSC
950
951
QGLSLRLQRF FLDKQRLLDR IHSITAERLI FSHAVQMVQS AALDEMFQHR
1000
1001
EGCVPRYHKA LLLLEGLQHM LSDQADIENV TKCKLCIERR LSALLTGICA
1050
1051
                                                      
1050
 

Show the unformatted sequence.

Checksums:
CRC64:AED9BD5139F2DB92
MD5:eaf7bf4ae65244dfebe5fd03f1e42a58

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 16 - 278 4WNO A 16 - 278 Jmol OpenAstexViewer
4WNP A 16 - 278 Jmol OpenAstexViewer
B 16 - 278 Jmol OpenAstexViewer
C 16 - 278 Jmol OpenAstexViewer
D 16 - 278 Jmol OpenAstexViewer
5CI7 A 16 - 278 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.