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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DPOLQ_HUMAN (O75417)

Summary

This is the summary of UniProt entry DPOLQ_HUMAN (O75417).

Description: DNA polymerase theta {ECO:0000303|PubMed:10395804, ECO:0000303|PubMed:14576298, ECO:0000312|HGNC:HGNC:9186}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2590 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 2 8
low_complexity n/a 5 19
disorder n/a 10 22
low_complexity n/a 13 30
disorder n/a 31 33
Pfam DEAD 93 274
Pfam Helicase_C 324 485
Pfam HTH_61 490 596
disorder n/a 606 607
low_complexity n/a 845 855
disorder n/a 850 851
low_complexity n/a 904 917
disorder n/a 929 931
disorder n/a 935 936
disorder n/a 955 957
disorder n/a 959 961
disorder n/a 967 973
disorder n/a 994 1036
disorder n/a 1039 1065
disorder n/a 1078 1079
disorder n/a 1084 1085
disorder n/a 1089 1091
disorder n/a 1094 1106
disorder n/a 1108 1110
disorder n/a 1176 1177
disorder n/a 1179 1180
disorder n/a 1182 1211
disorder n/a 1238 1240
disorder n/a 1246 1256
disorder n/a 1270 1275
disorder n/a 1285 1292
low_complexity n/a 1294 1306
disorder n/a 1296 1303
disorder n/a 1335 1337
disorder n/a 1369 1372
disorder n/a 1403 1405
disorder n/a 1470 1478
low_complexity n/a 1486 1497
disorder n/a 1505 1516
disorder n/a 1518 1520
disorder n/a 1533 1552
disorder n/a 1585 1623
low_complexity n/a 1599 1613
disorder n/a 1649 1651
coiled_coil n/a 1658 1688
disorder n/a 1660 1684
disorder n/a 1686 1689
disorder n/a 1692 1696
disorder n/a 1699 1737
disorder n/a 1739 1741
disorder n/a 1745 1748
disorder n/a 1758 1760
disorder n/a 1772 1773
disorder n/a 1776 1781
disorder n/a 1783 1794
disorder n/a 1796 1797
low_complexity n/a 1819 1826
Pfam DNA_pol_A 2096 2584
disorder n/a 2149 2165
disorder n/a 2240 2246
disorder n/a 2260 2261
disorder n/a 2275 2277
disorder n/a 2455 2456
disorder n/a 2506 2513
low_complexity n/a 2545 2558
low_complexity n/a 2566 2577

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75417. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNLLRRSGKR RRSESGSDSF SGSGGDSSAS PQFLSGSVLS PPPGLGRCLK
50
51
AAAAGECKPT VPDYERDKLL LANWGLPKAV LEKYHSFGVK KMFEWQAECL
100
101
LLGQVLEGKN LVYSAPTSAG KTLVAELLIL KRVLEMRKKA LFILPFVSVA
150
151
KEKKYYLQSL FQEVGIKVDG YMGSTSPSRH FSSLDIAVCT IERANGLINR
200
201
LIEENKMDLL GMVVVDELHM LGDSHRGYLL ELLLTKICYI TRKSASCQAD
250
251
LASSLSNAVQ IVGMSATLPN LELVASWLNA ELYHTDFRPV PLLESVKVGN
300
301
SIYDSSMKLV REFEPMLQVK GDEDHVVSLC YETICDNHSV LLFCPSKKWC
350
351
EKLADIIARE FYNLHHQAEG LVKPSECPPV ILEQKELLEV MDQLRRLPSG
400
401
LDSVLQKTVP WGVAFHHAGL TFEERDIIEG AFRQGLIRVL AATSTLSSGV
450
451
NLPARRVIIR TPIFGGRPLD ILTYKQMVGR AGRKGVDTVG ESILICKNSE
500
501
KSKGIALLQG SLKPVRSCLQ RREGEEVTGS MIRAILEIIV GGVASTSQDM
550
551
HTYAACTFLA ASMKEGKQGI QRNQESVQLG AIEACVMWLL ENEFIQSTEA
600
601
SDGTEGKVYH PTHLGSATLS SSLSPADTLD IFADLQRAMK GFVLENDLHI
650
651
LYLVTPMFED WTTIDWYRFF CLWEKLPTSM KRVAELVGVE EGFLARCVKG
700
701
KVVARTERQH RQMAIHKRFF TSLVLLDLIS EVPLREINQK YGCNRGQIQS
750
751
LQQSAAVYAG MITVFSNRLG WHNMELLLSQ FQKRLTFGIQ RELCDLVRVS
800
801
LLNAQRARVL YASGFHTVAD LARANIVEVE VILKNAVPFK SARKAVDEEE
850
851
EAVEERRNMR TIWVTGRKGL TEREAAALIV EEARMILQQD LVEMGVQWNP
900
901
CALLHSSTCS LTHSESEVKE HTFISQTKSS YKKLTSKNKS NTIFSDSYIK
950
951
HSPNIVQDLN KSREHTSSFN CNFQNGNQEH QTCSIFRARK RASLDINKEK
1000
1001
PGASQNEGKT SDKKVVQTFS QKTKKAPLNF NSEKMSRSFR SWKRRKHLKR
1050
1051
SRDSSPLKDS GACRIHLQGQ TLSNPSLCED PFTLDEKKTE FRNSGPFAKN
1100
1101
VSLSGKEKDN KTSFPLQIKQ NCSWNITLTN DNFVEHIVTG SQSKNVTCQA
1150
1151
TSVVSEKGRG VAVEAEKINE VLIQNGSKNQ NVYMKHHDIH PINQYLRKQS
1200
1201
HEQTSTITKQ KNIIERQMPC EAVSSYINRD SNVTINCERI KLNTEENKPS
1250
1251
HFQALGDDIS RTVIPSEVLP SAGAFSKSEG QHENFLNISR LQEKTGTYTT
1300
1301
NKTKNNHVSD LGLVLCDFED SFYLDTQSEK IIQQMATENA KLGAKDTNLA
1350
1351
AGIMQKSLVQ QNSMNSFQKE CHIPFPAEQH PLGATKIDHL DLKTVGTMKQ
1400
1401
SSDSHGVDIL TPESPIFHSP ILLEENGLFL KKNEVSVTDS QLNSFLQGYQ
1450
1451
TQETVKPVIL LIPQKRTPTG VEGECLPVPE TSLNMSDSLL FDSFSDDYLV
1500
1501
KEQLPDMQMK EPLPSEVTSN HFSDSLCLQE DLIKKSNVNE NQDTHQQLTC
1550
1551
SNDESIIFSE MDSVQMVEAL DNVDIFPVQE KNHTVVSPRA LELSDPVLDE
1600
1601
HHQGDQDGGD QDERAEKSKL TGTRQNHSFI WSGASFDLSP GLQRILDKVS
1650
1651
SPLENEKLKS MTINFSSLNR KNTELNEEQE VISNLETKQV QGISFSSNNE
1700
1701
VKSKIEMLEN NANHDETSSL LPRKESNIVD DNGLIPPTPI PTSASKLTFP
1750
1751
GILETPVNPW KTNNVLQPGE SYLFGSPSDI KNHDLSPGSR NGFKDNSPIS
1800
1801
DTSFSLQLSQ DGLQLTPASS SSESLSIIDV ASDQNLFQTF IKEWRCKKRF
1850
1851
SISLACEKIR SLTSSKTATI GSRFKQASSP QEIPIRDDGF PIKGCDDTLV
1900
1901
VGLAVCWGGR DAYYFSLQKE QKHSEISASL VPPSLDPSLT LKDRMWYLQS
1950
1951
CLRKESDKEC SVVIYDFIQS YKILLLSCGI SLEQSYEDPK VACWLLDPDS
2000
2001
QEPTLHSIVT SFLPHELPLL EGMETSQGIQ SLGLNAGSEH SGRYRASVES
2050
2051
ILIFNSMNQL NSLLQKENLQ DVFRKVEMPS QYCLALLELN GIGFSTAECE
2100
2101
SQKHIMQAKL DAIETQAYQL AGHSFSFTSS DDIAEVLFLE LKLPPNREMK
2150
2151
NQGSKKTLGS TRRGIDNGRK LRLGRQFSTS KDVLNKLKAL HPLPGLILEW
2200
2201
RRITNAITKV VFPLQREKCL NPFLGMERIY PVSQSHTATG RITFTEPNIQ
2250
2251
NVPRDFEIKM PTLVGESPPS QAVGKGLLPM GRGKYKKGFS VNPRCQAQME
2300
2301
ERAADRGMPF SISMRHAFVP FPGGSILAAD YSQLELRILA HLSHDRRLIQ
2350
2351
VLNTGADVFR SIAAEWKMIE PESVGDDLRQ QAKQICYGII YGMGAKSLGE
2400
2401
QMGIKENDAA CYIDSFKSRY TGINQFMTET VKNCKRDGFV QTILGRRRYL
2450
2451
PGIKDNNPYR KAHAERQAIN TIVQGSAADI VKIATVNIQK QLETFHSTFK
2500
2501
SHGHREGMLQ SDQTGLSRKR KLQGMFCPIR GGFFILQLHD ELLYEVAEED
2550
2551
VVQVAQIVKN EMESAVKLSV KLKVKVKIGA SWGELKDFDV           
2590
 

Show the unformatted sequence.

Checksums:
CRC64:F5550BED2DAD8013
MD5:b5b13cded60832c617b450167c09fe73

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DEAD 93 - 274 5A9F A 93 - 274 Show 3D Structure View in InterPro
5A9J A 93 - 274 Show 3D Structure View in InterPro
B 93 - 274 Show 3D Structure View in InterPro
C 93 - 274 Show 3D Structure View in InterPro
D 93 - 274 Show 3D Structure View in InterPro
5AGA A 93 - 274 Show 3D Structure View in InterPro
DNA_pol_A 2096 - 2584 4X0P A 2096 - 2584 Show 3D Structure View in InterPro
B 2096 - 2584 Show 3D Structure View in InterPro
C 2096 - 2584 Show 3D Structure View in InterPro
D 2096 - 2584 Show 3D Structure View in InterPro
4X0Q A 2096 - 2584 Show 3D Structure View in InterPro
B 2096 - 2584 Show 3D Structure View in InterPro
6XBU A 2096 - 2584 Show 3D Structure View in InterPro
Helicase_C 324 - 485 5A9F A 324 - 485 Show 3D Structure View in InterPro
5A9J A 324 - 485 Show 3D Structure View in InterPro
B 324 - 485 Show 3D Structure View in InterPro
C 324 - 485 Show 3D Structure View in InterPro
D 324 - 485 Show 3D Structure View in InterPro
5AGA A 324 - 485 Show 3D Structure View in InterPro
HTH_61 490 - 596 5A9F A 490 - 596 Show 3D Structure View in InterPro
5A9J A 490 - 596 Show 3D Structure View in InterPro
B 490 - 596 Show 3D Structure View in InterPro
C 490 - 596 Show 3D Structure View in InterPro
D 490 - 596 Show 3D Structure View in InterPro
5AGA A 490 - 596 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;