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19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PSIP1_HUMAN (O75475)

Summary

This is the summary of UniProt entry PSIP1_HUMAN (O75475).

Description: PC4 and SFRS1-interacting protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 530 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam PWWP 5 89
disorder n/a 23 32
disorder n/a 63 81
disorder n/a 84 86
disorder n/a 88 358
low_complexity n/a 104 121
low_complexity n/a 142 154
low_complexity n/a 156 169
low_complexity n/a 212 243
low_complexity n/a 238 257
low_complexity n/a 266 290
coiled_coil n/a 308 329
low_complexity n/a 328 344
Pfam LEDGF 349 450
disorder n/a 360 361
disorder n/a 382 400
disorder n/a 438 530

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75475. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET
50
51
AFLGPKDIFP YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK
100
101
QSNASSDVEV EEKETSVSKE DTDHEEKASN EDVTKAVDIT TPKAARRGRK
150
151
RKAEKQVETE EAGVVTTATA SVNLKVSPKR GRPAATEVKI PKPRGRPKMV
200
201
KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE EDKPRKEPDK
250
251
KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR
300
301
NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS
350
351
RLQRIHAEIK NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL
400
401
KKIRRFKVSQ VIMEKSTMLY NKFKNMFLVG EGDSVITQVL NKSLAEQRQH
450
451
EEANKTKDQG KKGPNKKLEK EQTGSKTLNG GSDAQDGNQP QHNGESNEDS
500
501
KDNHEASTKK KPSSEERETE ISLKDSTLDN                      
530
 

Show the unformatted sequence.

Checksums:
CRC64:4B653D02B1D0E174
MD5:6266d7d911ca0ebd0a842ff3bb63c08c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
LEDGF 349 - 413 3HPG L 349 - 413 Jmol OpenAstexViewer
349 - 418 3HPG H 349 - 418 Jmol OpenAstexViewer
I 349 - 418 Jmol OpenAstexViewer
349 - 423 3HPG G 349 - 423 Jmol OpenAstexViewer
J 349 - 423 Jmol OpenAstexViewer
349 - 424 5N88 E 349 - 424 Jmol OpenAstexViewer
349 - 425 5N88 D 349 - 425 Jmol OpenAstexViewer
349 - 426 2B4J C 349 - 426 Jmol OpenAstexViewer
D 349 - 426 Jmol OpenAstexViewer
2MSR B 349 - 426 Jmol OpenAstexViewer
2N3A B 349 - 426 Jmol OpenAstexViewer
3HPG K 349 - 426 Jmol OpenAstexViewer
349 - 427 5OYM B 349 - 427 Jmol OpenAstexViewer
349 - 429 1Z9E A 349 - 429 Jmol OpenAstexViewer
3U88 C 349 - 429 Jmol OpenAstexViewer
5OYM A 349 - 429 Jmol OpenAstexViewer
C 349 - 429 Jmol OpenAstexViewer
H 349 - 429 Jmol OpenAstexViewer
349 - 430 5OYM D 349 - 430 Jmol OpenAstexViewer
E 349 - 430 Jmol OpenAstexViewer
F 349 - 430 Jmol OpenAstexViewer
349 - 431 5OYM G 349 - 431 Jmol OpenAstexViewer
349 - 435 3F9K a 349 - 435 Jmol OpenAstexViewer
C 349 - 435 Jmol OpenAstexViewer
e 349 - 435 Jmol OpenAstexViewer
G 349 - 435 Jmol OpenAstexViewer
i 349 - 435 Jmol OpenAstexViewer
K 349 - 435 Jmol OpenAstexViewer
m 349 - 435 Jmol OpenAstexViewer
O 349 - 435 Jmol OpenAstexViewer
q 349 - 435 Jmol OpenAstexViewer
S 349 - 435 Jmol OpenAstexViewer
u 349 - 435 Jmol OpenAstexViewer
W 349 - 435 Jmol OpenAstexViewer
3HPH E 349 - 435 Jmol OpenAstexViewer
H 349 - 435 Jmol OpenAstexViewer
349 - 436 2MTN A 349 - 436 Jmol OpenAstexViewer
349 - 442 5YI9 A 349 - 442 Jmol OpenAstexViewer
6EMO A 349 - 442 Jmol OpenAstexViewer
6EMP A 349 - 442 Jmol OpenAstexViewer
6EMR A 349 - 442 Jmol OpenAstexViewer
349 - 443 6EMQ A 349 - 449 Jmol OpenAstexViewer
352 - 426 3HPH F 352 - 426 Jmol OpenAstexViewer
353 - 420 3HPH G 353 - 420 Jmol OpenAstexViewer
353 - 430 3U88 D 353 - 430 Jmol OpenAstexViewer
PWWP 5 - 89 2M16 A 5 - 89 Jmol OpenAstexViewer
3ZEH A 5 - 89 Jmol OpenAstexViewer
4FU6 A 5 - 89 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.