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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SF3B1_HUMAN (O75533)

Summary

This is the summary of UniProt entry SF3B1_HUMAN (O75533).

Description: Splicing factor 3B subunit 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1304 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
coiled_coil n/a 1 28
disorder n/a 15 19
disorder n/a 36 37
disorder n/a 55 58
disorder n/a 62 78
low_complexity n/a 65 75
disorder n/a 81 82
disorder n/a 87 93
disorder n/a 95 412
Pfam SF3b1 329 452
disorder n/a 415 421
disorder n/a 423 463
disorder n/a 513 516
transmembrane n/a 631 652
transmembrane n/a 664 683
low_complexity n/a 706 716
coiled_coil n/a 847 874
low_complexity n/a 1061 1066

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75533. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAKIAKTHED IEAQIREIQG KKAALDEAQG VGLDSTGYYD QEIYGGSDSR
50
51
FAGYVTSIAA TELEDDDDDY SSSTSLLGQK KPGYHAPVAL LNDIPQSTEQ
100
101
YDPFAEHRPP KIADREDEYK KHRRTMIISP ERLDPFADGG KTPDPKMNAR
150
151
TYMDVMREQH LTKEEREIRQ QLAEKAKAGE LKVVNGAAAS QPPSKRKRRW
200
201
DQTADQTPGA TPKKLSSWDQ AETPGHTPSL RWDETPGRAK GSETPGATPG
250
251
SKIWDPTPSH TPAGAATPGR GDTPGHATPG HGGATSSARK NRWDETPKTE
300
301
RDTPGHGSGW AETPRTDRGG DSIGETPTPG ASKRKSRWDE TPASQMGGST
350
351
PVLTPGKTPI GTPAMNMATP TPGHIMSMTP EQLQAWRWER EIDERNRPLS
400
401
DEELDAMFPE GYKVLPPPAG YVPIRTPARK LTATPTPLGG MTGFHMQTED
450
451
RTMKSVNDQP SGNLPFLKPD DIQYFDKLLV DVDESTLSPE EQKERKIMKL
500
501
LLKIKNGTPP MRKAALRQIT DKAREFGAGP LFNQILPLLM SPTLEDQERH
550
551
LLVKVIDRIL YKLDDLVRPY VHKILVVIEP LLIDEDYYAR VEGREIISNL
600
601
AKAAGLATMI STMRPDIDNM DEYVRNTTAR AFAVVASALG IPSLLPFLKA
650
651
VCKSKKSWQA RHTGIKIVQQ IAILMGCAIL PHLRSLVEII EHGLVDEQQK
700
701
VRTISALAIA ALAEAATPYG IESFDSVLKP LWKGIRQHRG KGLAAFLKAI
750
751
GYLIPLMDAE YANYYTREVM LILIREFQSP DEEMKKIVLK VVKQCCGTDG
800
801
VEANYIKTEI LPPFFKHFWQ HRMALDRRNY RQLVDTTVEL ANKVGAAEII
850
851
SRIVDDLKDE AEQYRKMVME TIEKIMGNLG AADIDHKLEE QLIDGILYAF
900
901
QEQTTEDSVM LNGFGTVVNA LGKRVKPYLP QICGTVLWRL NNKSAKVRQQ
950
951
AADLISRTAV VMKTCQEEKL MGHLGVVLYE YLGEEYPEVL GSILGALKAI
1000
1001
VNVIGMHKMT PPIKDLLPRL TPILKNRHEK VQENCIDLVG RIADRGAEYV
1050
1051
SAREWMRICF ELLELLKAHK KAIRRATVNT FGYIAKAIGP HDVLATLLNN
1100
1101
LKVQERQNRV CTTVAIAIVA ETCSPFTVLP ALMNEYRVPE LNVQNGVLKS
1150
1151
LSFLFEYIGE MGKDYIYAVT PLLEDALMDR DLVHRQTASA VVQHMSLGVY
1200
1201
GFGCEDSLNH LLNYVWPNVF ETSPHVIQAV MGALEGLRVA IGPCRMLQYC
1250
1251
LQGLFHPARK VRDVYWKIYN SIYIGSQDAL IAHYPRIYND DKNTYIRYEL
1300
1301
DYIL                                                  
1304
 

Show the unformatted sequence.

Checksums:
CRC64:12F051757D2B9DEE
MD5:104b78e518abdd250a09664617076838

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SF3b1 329 - 440 7ABH u 329 - 440 Show 3D Structure View in InterPro
329 - 449 5Z56 1 329 - 449 Show 3D Structure View in InterPro
5Z57 1 329 - 449 Show 3D Structure View in InterPro
5Z58 1 329 - 449 Show 3D Structure View in InterPro
333 - 342 2PEH C 333 - 342 Show 3D Structure View in InterPro
334 - 342 2PEH D 334 - 342 Show 3D Structure View in InterPro
335 - 342 4OZ1 C 335 - 342 Show 3D Structure View in InterPro
336 - 339 6N3F D 336 - 339 Show 3D Structure View in InterPro
377 - 415 2F9D P 377 - 415 Show 3D Structure View in InterPro
Q 377 - 415 Show 3D Structure View in InterPro
3LQV P 377 - 415 Show 3D Structure View in InterPro
379 - 415 3LQV Q 379 - 415 Show 3D Structure View in InterPro
379 - 424 2FHO A 379 - 424 Show 3D Structure View in InterPro
381 - 415 2F9J P 381 - 415 Show 3D Structure View in InterPro
389 - 415 2F9J Q 389 - 415 Show 3D Structure View in InterPro
394 - 447 6AH0 1 394 - 447 Show 3D Structure View in InterPro
398 - 452 6FF4 u 398 - 452 Show 3D Structure View in InterPro
6FF7 u 398 - 452 Show 3D Structure View in InterPro
399 - 419 6Y53 u 399 - 419 Show 3D Structure View in InterPro
6Y5Q u 399 - 419 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;