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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: GRAP2_HUMAN (O75791)

Summary

This is the summary of UniProt entry GRAP2_HUMAN (O75791).

Description: GRB2-related adapter protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 330 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam SH3_1 4 48
Pfam SH2 58 132
disorder n/a 142 268
low_complexity n/a 188 226
Pfam SH3_1 277 322
disorder n/a 295 296

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75791. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF
50
51
IDIQFPKWFH EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED
100
101
DVQHFKVMRD NKGNYFLWTE KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR
150
151
EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP SMNRKLSDHP PTLPLQQHQH
200
201
QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN DGHCGTGLGS
250
251
EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV
300
301
LDSSNPSWWT GRLHNKLGLF PANYVAPMTR                      
330
 

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Checksums:
CRC64:74F4C8D0EBB56D55
MD5:72d6308d72a998d9432794ae32578067

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SH2 58 - 132 5GJH A 58 - 132 Jmol OpenAstexViewer
C 58 - 132 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.