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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EIF3G_HUMAN (O75821)

Summary

This is the summary of UniProt entry EIF3G_HUMAN (O75821).

Description: Eukaryotic translation initiation factor 3 subunit G {ECO:0000255|HAMAP-Rule:MF_03006}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 320 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 66
low_complexity n/a 42 57
Pfam eIF3g 56 175
disorder n/a 102 125
disorder n/a 131 148
disorder n/a 170 174
disorder n/a 180 247
Pfam RRM_1 241 310

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75821. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPTGDFDSKP SWADQVEEEG EDDKCVTSEL LKGIPLATGD TSPEPELLPG
50
51
APLPPPKEVI NGNIKTVTEY KIDEDGKKFK IVRTFRIETR KASKAVARRK
100
101
NWKKFGNSEF DPPGPNVATT TVSDDVSMTF ITSKEDLNCQ EEEDPMNKLK
150
151
GQKIVSCRIC KGDHWTTRCP YKDTLGPMQK ELAEQLGLST GEKEKLPGEL
200
201
EPVQATQNKT GKYVPPSLRD GASRRGESMQ PNRRADDNAT IRVTNLSEDT
250
251
RETDLQELFR PFGSISRIYL AKDKTTGQSK GFAFISFHRR EDAARAIAGV
300
301
SGFGYDHLIL NVEWAKPSTN                                 
320
 

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Checksums:
CRC64:7D7226FEDE9D6FBB
MD5:c9692cbaa44f5808cb0e96685a87e652

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
eIF3g 103 - 140 5K0Y M 103 - 140 Jmol OpenAstexViewer
153 - 175 2MJC A 9 - 31 Jmol OpenAstexViewer
RRM_1 241 - 310 2CQ0 A 241 - 310 Jmol OpenAstexViewer
5K0Y O 241 - 310 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.