Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FACE1_HUMAN (O75844)

Summary

This is the summary of UniProt entry FACE1_HUMAN (O75844).

Description: CAAX prenyl protease 1 homolog EC=3.4.24.84
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 475 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
transmembrane n/a 20 38
Pfam Peptidase_M48_N 41 225
transmembrane n/a 77 102
transmembrane n/a 122 144
low_complexity n/a 122 138
transmembrane n/a 171 189
transmembrane n/a 195 216
low_complexity n/a 201 212
Pfam Peptidase_M48 228 473
disorder n/a 298 317
low_complexity n/a 300 311
transmembrane n/a 357 379
low_complexity n/a 384 395
transmembrane n/a 385 410

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75844. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGMWASLDAL WEMPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTH
50
51
VPPELGQIMD SETFEKSRLY QLDKSTFSFW SGLYSETEGT LILLFGGIPY
100
101
LWRLSGRFCG YAGFGPEYEI TQSLVFLLLA TLFSALTGLP WSLYNTFVIE
150
151
EKHGFNQQTL GFFMKDAIKK FVVTQCILLP VSSLLLYIIK IGGDYFFIYA
200
201
WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKEEIEV MAKSIDFPLT
250
251
KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVL NKDIQEDSGM
300
301
EPRNEEEGNS EEIKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII
350
351
ISQMNSFLCF FLFAVLIGRK ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN
400
401
EVLSFCLTVL SRRFEFQADA FAKKLGKAKD LYSALIKLNK DNLGFPVSDW
450
451
LFSMWHYSHP PLLERLQALK TMKQH                           
475
 

Show the unformatted sequence.

Checksums:
CRC64:6C49179DEB0C8F7F
MD5:f2f14d9392686e12a0af19207344a124

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_M48 228 - 471 2YPT D 228 - 471 Jmol OpenAstexViewer
E 228 - 471 Jmol OpenAstexViewer
4AW6 D 228 - 471 Jmol OpenAstexViewer
E 228 - 471 Jmol OpenAstexViewer
228 - 472 2YPT A 228 - 472 Jmol OpenAstexViewer
B 228 - 472 Jmol OpenAstexViewer
4AW6 A 228 - 472 Jmol OpenAstexViewer
B 228 - 472 Jmol OpenAstexViewer
228 - 473 5SYT A 228 - 473 Jmol OpenAstexViewer
Peptidase_M48_N 41 - 225 2YPT A 41 - 225 Jmol OpenAstexViewer
B 41 - 225 Jmol OpenAstexViewer
D 41 - 225 Jmol OpenAstexViewer
E 41 - 225 Jmol OpenAstexViewer
4AW6 A 41 - 225 Jmol OpenAstexViewer
B 41 - 225 Jmol OpenAstexViewer
D 41 - 225 Jmol OpenAstexViewer
E 41 - 225 Jmol OpenAstexViewer
5SYT A 41 - 225 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.