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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PPR37_HUMAN (O75864)

Summary

This is the summary of UniProt entry PPR37_HUMAN (O75864).

Description: Protein phosphatase 1 regulatory subunit 37
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 691 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 43
low_complexity n/a 19 35
disorder n/a 52 67
coiled_coil n/a 124 144
Pfam LRR_6 274 297
Pfam LRR_6 331 354
Pfam LRR_6 387 410
disorder n/a 430 433
disorder n/a 454 691
low_complexity n/a 496 525
low_complexity n/a 539 552
low_complexity n/a 575 607
low_complexity n/a 620 634
low_complexity n/a 637 658
low_complexity n/a 665 689

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75864. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEIAPQEAPP VPGADGDIEE APAEAGSPSP ASPPADGRLK AAAKRVTFPS
50
51
DEDIVSGAVE PKDPWRHAQN VTVDEVIGAY KQACQKLNCR QIPKLLRQLQ
100
101
EFTDLGHRLD CLDLKGEKLD YKTCEALEEV FKRLQFKVVD LEQTNLDEDG
150
151
ASALFDMIEY YESATHLNIS FNKHIGTRGW QAAAHMMRKT SCLQYLDARN
200
201
TPLLDHSAPF VARALRIRSS LAVLHLENAS LSGRPLMLLA TALKMNMNLR
250
251
ELYLADNKLN GLQDSAQLGN LLKFNCSLQI LDLRNNHVLD SGLAYICEGL
300
301
KEQRKGLVTL VLWNNQLTHT GMAFLGMTLP HTQSLETLNL GHNPIGNEGV
350
351
RHLKNGLISN RSVLRLGLAS TKLTCEGAVA VAEFIAESPR LLRLDLRENE
400
401
IKTGGLMALS LALKVNHSLL RLDLDREPKK EAVKSFIETQ KALLAEIQNG
450
451
CKRNLVLARE REEKEQPPQL SASMPETTAT EPQPDDEPAA GVQNGAPSPA
500
501
PSPDSDSDSD SDGEEEEEEE GERDETPCPA LVPPTDSLGP GDRSPPGSPS
550
551
TPTEQRISVS SPGRGHKVFV VTRVESPPER AEPPASPTPP SPPPPPSPPA
600
601
SPSLPPAGAI DTRDTGSSEP QPPPEPPRSG PPLPNGLKPE FALALPPEPP
650
651
PGPEVKGGSC GLEHELSCSK NEKELEELLL EASQESGQET L         
691
 

Show the unformatted sequence.

Checksums:
CRC64:45578CC726B2063F
MD5:db2ef3d58a1879b5e09b97178815010b

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;