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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: STAM2_HUMAN (O75886)

Summary

This is the summary of UniProt entry STAM2_HUMAN (O75886).

Description: Signal transducing adapter molecule 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 525 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam VHS 4 140
disorder n/a 146 166
Pfam UIM 165 181
disorder n/a 169 179
disorder n/a 184 194
Pfam SH3_1 208 253
disorder n/a 285 291
disorder n/a 302 308
disorder n/a 312 321
disorder n/a 333 341
coiled_coil n/a 333 353
disorder n/a 376 378
disorder n/a 381 403
disorder n/a 422 525

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75886. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI
50
51
MKRVNHKVPH VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK
100
101
AHPKVCEKLK SLMVEWSEEF QKDPQFSLIS ATIKSMKEEG ITFPPAGSQT
150
151
VSAAAKNGTS SNKNKEDEDI AKAIELSLQE QKQQHTETKS LYPSSEIQLN
200
201
NKVARKVRAL YDFEAVEDNE LTFKHGEIII VLDDSDANWW KGENHRGIGL
250
251
FPSNFVTTNL NIETEAAAVD KLNVIDDDVE EIKKSEPEPV YIDEDKMDRA
300
301
LQVLQSIDPT DSKPDSQDLL DLEDICQQMG PMIDEKLEEI DRKHSELSEL
350
351
NVKVLEALEL YNKLVNEAPV YSVYSKLHPP AHYPPASSGV PMQTYPVQSH
400
401
GGNYMGQSIH QVTVAQSYSL GPDQIGPLRS LPPNVNSSVT AQPAQTSYLS
450
451
TGQDTVSNPT YMNQNSNLQS ATGTTAYTQQ MGMSVDMSSY QNTTSNLPQL
500
501
AGFPVTVPAH PVAQQHTNYH QQPLL                           
525
 

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Checksums:
CRC64:408D484544DD9403
MD5:9cc475215e0cff2aad606aa854b6ec0c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SH3_1 208 - 253 1X2Q A 21 - 66 Jmol OpenAstexViewer
5IXF A 215 - 260 Jmol OpenAstexViewer
VHS 4 - 140 1X5B A 11 - 147 Jmol OpenAstexViewer
2L0T B 11 - 147 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.