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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPF30_HUMAN (O75940)

Summary

This is the summary of UniProt entry SPF30_HUMAN (O75940).

Description: Survival of motor neuron-related-splicing factor 30
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 238 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
coiled_coil n/a 2 22
low_complexity n/a 31 39
disorder n/a 50 52
disorder n/a 54 67
Pfam SMN 59 196
disorder n/a 69 70
disorder n/a 76 77
low_complexity n/a 91 100
disorder n/a 93 95
disorder n/a 119 120
disorder n/a 122 149
disorder n/a 151 152
low_complexity n/a 153 161
coiled_coil n/a 157 184
disorder n/a 158 166
disorder n/a 168 183
disorder n/a 192 199
disorder n/a 210 212
disorder n/a 216 218
disorder n/a 222 238

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75940. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL
50
51
STQPSETLAS SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE
100
101
NGTAAITFAG YGNAEVTPLL NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR
150
151
EYKKKKALKK AQRIKELEQE REDQKVKWQQ FNNRAYSKNK KGQVKRSIFA
200
201
SPESVTGKVG VGTCGIADKP MTQYQDTSKY NVRHLMPQ             
238
 

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Checksums:
CRC64:7F60852AD4D1F53A
MD5:b022309849927c83d9833edce0bd477b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SMN 65 - 128 4A4F A 65 - 128 Show 3D Structure View in InterPro
4A4H A 65 - 128 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;