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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MPDZ_HUMAN (O75970)

Summary

This is the summary of UniProt entry MPDZ_HUMAN (O75970).

Description: Multiple PDZ domain protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2070 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam L27_2 6 63
disorder n/a 15 24
disorder n/a 105 110
Pfam PDZ 137 221
disorder n/a 176 178
disorder n/a 243 247
disorder n/a 254 255
Pfam PDZ 257 334
low_complexity n/a 263 277
disorder n/a 345 354
low_complexity n/a 351 358
disorder n/a 357 370
disorder n/a 372 377
Pfam PDZ 376 460
disorder n/a 442 443
disorder n/a 470 477
disorder n/a 501 508
coiled_coil n/a 520 540
disorder n/a 521 523
disorder n/a 646 647
disorder n/a 662 664
disorder n/a 672 682
disorder n/a 688 689
Pfam PDZ 700 784
coiled_coil n/a 754 774
disorder n/a 765 768
disorder n/a 782 783
disorder n/a 836 848
disorder n/a 871 874
disorder n/a 876 882
disorder n/a 884 886
disorder n/a 905 912
disorder n/a 914 925
disorder n/a 968 969
Pfam PDZ 1008 1080
disorder n/a 1122 1143
low_complexity n/a 1122 1137
Pfam PDZ 1151 1240
disorder n/a 1196 1216
disorder n/a 1219 1225
disorder n/a 1273 1322
low_complexity n/a 1297 1301
Pfam PDZ 1350 1429
disorder n/a 1362 1364
disorder n/a 1441 1442
disorder n/a 1444 1445
disorder n/a 1447 1466
disorder n/a 1468 1469
Pfam PDZ 1482 1561
disorder n/a 1560 1565
Pfam MPDZ_u10 1562 1626
disorder n/a 1567 1578
disorder n/a 1580 1610
Pfam PDZ 1627 1709
Pfam PDZ 1725 1804
disorder n/a 1807 1826
low_complexity n/a 1817 1829
low_complexity n/a 1834 1855
disorder n/a 1839 1842
disorder n/a 1844 1851
disorder n/a 1858 1861
Pfam PDZ 1862 1945
disorder n/a 1951 1953
disorder n/a 1957 1958
low_complexity n/a 1961 1973
disorder n/a 1963 1964
Pfam PDZ 1987 2069

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O75970. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLEAIDKNRA LHAAERLQTK LRERGDVANE DKLSLLKSVL QSPLFSQILS
50
51
LQTSVQQLKD QVNIATSATS NIEYAHVPHL SPAVIPTLQN ESFLLSPNNG
100
101
NLEALTGPGI PHINGKPACD EFDQLIKNMA QGRHVEVFEL LKPPSGGLGF
150
151
SVVGLRSENR GELGIFVQEI QEGSVAHRDG RLKETDQILA INGQALDQTI
200
201
THQQAISILQ KAKDTVQLVI ARGSLPQLVS PIVSRSPSAA STISAHSNPV
250
251
HWQHMETIEL VNDGSGLGFG IIGGKATGVI VKTILPGGVA DQHGRLCSGD
300
301
HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE RTAPTALGIT
350
351
LSSSPTSTPE LRVDASTQKG EESETFDVEL TKNVQGLGIT IAGYIGDKKL
400
401
EPSGIFVKSI TKSSAVEHDG RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH
450
451
TGQTVLLTLM RRGMKQEAEL MSREDVTKDA DLSPVNASII KENYEKDEDF
500
501
LSSTRNTNIL PTEEEGYPLL SAEIEEIEDA QKQEAALLTK WQRIMGINYE
550
551
IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL
600
601
EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTTQ SELDSLDLCD
650
651
IELTEKPHVD LGEFIGSSET EDPVLAMTDA GQSTEEVQAP LAMWEAGIQH
700
701
IELEKGSKGL GFSILDYQDP IDPASTVIII RSLVPGGIAE KDGRLLPGDR
750
751
LMFVNDVNLE NSSLEEAVEA LKGAPSGTVR IGVAKPLPLS PEEGYVSAKE
800
801
DSFLYPPHSC EEAGLADKPL FRADLALVGT NDADLVDEST FESPYSPEND
850
851
SIYSTQASIL SLHGSSCGDG LNYGSSLPSS PPKDVIENSC DPVLDLHMSL
900
901
EELYTQNLLQ RQDENTPSVD ISMGPASGFT INDYTPANAI EQQYECENTI
950
951
VWTESHLPSE VISSAELPSV LPDSAGKGSE YLLEQSSLAC NAECVMLQNV
1000
1001
SKESFERTIN IAKGNSSLGM TVSANKDGLG MIVRSIIHGG AISRDGRIAI
1050
1051
GDCILSINEE STISVTNAQA RAMLRRHSLI GPDIKITYVP AEHLEEFKIS
1100
1101
LGQQSGRVMA LDIFSSYTGR DIPELPEREE GEGEESELQN TAYSNWNQPR
1150
1151
RVELWREPSK SLGISIVGGR GMGSRLSNGE VMRGIFIKHV LEDSPAGKNG
1200
1201
TLKPGDRIVE VDGMDLRDAS HEQAVEAIRK AGNPVVFMVQ SIINRPRKSP
1250
1251
LPSLLHNLYP KYNFSSTNPF ADSLQINADK APSQSESEPE KAPLCSVPPP
1300
1301
PPSAFAEMGS DHTQSSASKI SQDVDKEDEF GYSWKNIRER YGTLTGELHM
1350
1351
IELEKGHSGL GLSLAGNKDR SRMSVFIVGI DPNGAAGKDG RLQIADELLE
1400
1401
INGQILYGRS HQNASSIIKC APSKVKIIFI RNKDAVNQMA VCPGNAVEPL
1450
1451
PSNSENLQNK ETEPTVTTSD AAVDLSSFKN VQHLELPKDQ GGLGIAISEE
1500
1501
DTLSGVIIKS LTEHGVAATD GRLKVGDQIL AVDDEIVVGY PIEKFISLLK
1550
1551
TAKMTVKLTI HAENPDSQAV PSAAGAASGE KKNSSQSLMV PQSGSPEPES
1600
1601
IRNTSRSSTP AIFASDPATC PIIPGCETTI EISKGRTGLG LSIVGGSDTL
1650
1651
LGAIIIHEVY EEGAACKDGR LWAGDQILEV NGIDLRKATH DEAINVLRQT
1700
1701
PQRVRLTLYR DEAPYKEEEV CDTLTIELQK KPGKGLGLSI VGKRNDTGVF
1750
1751
VSDIVKGGIA DADGRLMQGD QILMVNGEDV RNATQEAVAA LLKCSLGTVT
1800
1801
LEVGRIKAGP FHSERRPSQS SQVSEGSLSS FTFPLSGSST SESLESSSKK
1850
1851
NALASEIQGL RTVEMKKGPT DSLGISIAGG VGSPLGDVPI FIAMMHPTGV
1900
1901
AAQTQKLRVG DRIVTICGTS TEGMTHTQAV NLLKNASGSI EMQVVAGGDV
1950
1951
SVVTGHQQEP ASSSLSFTGL TSSSIFQDDL GPPQCKSITL ERGPDGLGFS
2000
2001
IVGGYGSPHG DLPIYVKTVF AKGAASEDGR LKRGDQIIAV NGQSLEGVTH
2050
2051
EEAVAILKRT KGTVTLMVLS                                 
2070
 

Show the unformatted sequence.

Checksums:
CRC64:A4D304C20401FD45
MD5:95d7f3e5f8fe3f7d863c1f21dcbf3185

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MPDZ_u10 1625 - 1626 2OPG A 1625 - 1626 Jmol OpenAstexViewer
B 1625 - 1626 Jmol OpenAstexViewer
PDZ 1151 - 1240 2FCF A 1151 - 1240 Jmol OpenAstexViewer
2IWQ A 1151 - 1240 Jmol OpenAstexViewer
137 - 221 2O2T A 137 - 221 Jmol OpenAstexViewer
B 137 - 221 Jmol OpenAstexViewer
1627 - 1709 2OPG A 1627 - 1709 Jmol OpenAstexViewer
B 1627 - 1709 Jmol OpenAstexViewer
1725 - 1804 2QG1 A 1725 - 1804 Jmol OpenAstexViewer
1862 - 1945 2IWO A 1834 - 1917 Jmol OpenAstexViewer
B 1834 - 1917 Jmol OpenAstexViewer
2IWP A 1834 - 1917 Jmol OpenAstexViewer
B 1834 - 1917 Jmol OpenAstexViewer
1987 - 2069 2FNE A 1959 - 2041 Jmol OpenAstexViewer
B 1959 - 2041 Jmol OpenAstexViewer
C 1959 - 2041 Jmol OpenAstexViewer
376 - 460 2IWN A 376 - 460 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.