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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: NEBL_HUMAN (O76041)

Summary

This is the summary of UniProt entry NEBL_HUMAN (O76041).

Description: Nebulette
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1014 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
low_complexity n/a 7 26
disorder n/a 11 22
disorder n/a 24 25
Pfam Nebulin 35 62
disorder n/a 136 140
disorder n/a 144 170
disorder n/a 172 176
disorder n/a 178 179
disorder n/a 203 204
Pfam Nebulin 213 240
disorder n/a 233 234
disorder n/a 236 238
disorder n/a 240 251
disorder n/a 274 275
disorder n/a 319 320
Pfam Nebulin 320 347
disorder n/a 336 340
low_complexity n/a 338 345
disorder n/a 354 357
Pfam Nebulin 356 384
disorder n/a 362 363
disorder n/a 365 367
disorder n/a 417 420
disorder n/a 427 428
disorder n/a 431 441
Pfam Nebulin 432 456
disorder n/a 443 445
disorder n/a 455 456
disorder n/a 461 478
Pfam Nebulin 467 495
disorder n/a 480 482
disorder n/a 491 494
disorder n/a 497 499
disorder n/a 501 515
Pfam Nebulin 504 532
disorder n/a 517 530
disorder n/a 532 534
disorder n/a 538 539
Pfam Nebulin 541 568
disorder n/a 542 543
disorder n/a 556 559
disorder n/a 566 568
disorder n/a 570 582
Pfam Nebulin 576 599
disorder n/a 605 619
Pfam Nebulin 607 629
disorder n/a 621 630
disorder n/a 632 633
disorder n/a 635 719
Pfam Nebulin 638 663
Pfam Nebulin 669 694
Pfam Nebulin 700 723
disorder n/a 725 726
disorder n/a 728 754
Pfam Nebulin 732 758
disorder n/a 756 771
Pfam Nebulin 766 793
disorder n/a 775 777
disorder n/a 781 785
disorder n/a 793 809
disorder n/a 811 817
disorder n/a 824 825
disorder n/a 855 856
disorder n/a 863 866
low_complexity n/a 874 887
disorder n/a 880 881
disorder n/a 887 892
disorder n/a 894 895
disorder n/a 918 927
disorder n/a 939 944
disorder n/a 949 951
Pfam SH3_9 961 1011
disorder n/a 978 979

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O76041. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRVPVFEDIK DETEEEKIGE EENEEDQVFY KPVIEDLSME LARKCTELIS
50
51
DIRYKEEFKK SKDKCTFVTD SPMLNHVKNI GAFISEAKYK GTIKADLSNS
100
101
LYKRMPATID SVFAGEVTQL QSEVAYKQKH DAAKGFSDYA HMKEPPEVKH
150
151
AMEVNKHQSN ISYRKDVQDT HTYSAELDRP DIKMATQISK IISNAEYKKG
200
201
QGIMNKEPAV IGRPDFEHAV EASKLSSQIK YKEKFDNEMK DKKHHYNPLE
250
251
SASFRQNQLA ATLASNVKYK KDIQNMHDPV SDLPNLLFLD HVLKASKMLS
300
301
GREYKKLFEE NKGMYHFDAD AVEHLHHKGN AVLQSQVKYK EEYEKNKGKP
350
351
MLEFVETPSY QASKEAQKMQ SEKVYKEDFE KEIKGRSSLD LDKTPEFLHV
400
401
KYITNLLREK EYKKDLENEI KGKGMELNSE VLDIQRAKRA SEMASEKEYK
450
451
KDLESIIKGK GMQAGTDTLE MQHAKKAAEI ASEKDYKRDL ETEIKGKGMQ
500
501
VSTDTLDVQR AKKASEMASQ KQYKKDLENE IKGKGMQVSM DIPDILRAKR
550
551
TSEIYSQRKY KDEAEKMLSN YSTIADTPEI QRIKTTQQNI SAVFYKKEVG
600
601
AGTAVKDSPE IERVKKNQQN ISSVKYKEEI KHATAISDPP ELKRVKENQK
650
651
NISNLQYKEQ NYKATPVSMT PEIERVRRNQ EQLSAVKYKG ELQRGTAISD
700
701
PPELKRAKEN QKNISNVYYR GQLGRATTLS VTPEMERVKK NQENISSVKY
750
751
TQDHKQMKGR PSLILDTPAM RHVKEAQNHI SMVKYHEDFE KTKGRGFTPV
800
801
VDDPVTERVR KNTQVVSDAA YKGVHPHIVE MDRRPGIIVD LKVWRTDPGS
850
851
IFDLDPLEDN IQSRSLHMLS EKASHYRRHW SRSHSSSTFG TGLGDDRSEI
900
901
SEIYPSFSCC SEVTRPSDEG APVLPGAYQQ SHSQGYGYMH QTSVSSMRSM
950
951
QHSPNLRTYR AMYDYSAQDE DEVSFRDGDY IVNVQPIDDG WMYGTVQRTG
1000
1001
RTGMLPANYI EFVN                                       
1014
 

Show the unformatted sequence.

Checksums:
CRC64:81712E38BC6AC9E1
MD5:e3a698addb734e9898cb7c8914e10ce0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SH3_9 961 - 1011 4F14 A 961 - 1011 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;