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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: FGF18_HUMAN (O76093)

Summary

This is the summary of UniProt entry FGF18_HUMAN (O76093).

Description: Fibroblast growth factor 18
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 207 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 27
low_complexity n/a 9 25
Pfam FGF 53 175
low_complexity n/a 153 165
disorder n/a 157 179
disorder n/a 186 207

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O76093. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK
50
51
QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK
100
101
GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY
150
151
VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQPELQKPFK YTTVTKRSRR
200
201
IRPTHPA                                               
207
 

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Checksums:
CRC64:57F69E7B30181500
MD5:7867b38ec2c29aa1af022b44d3577b51

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FGF 53 - 175 4CJM A 53 - 175 Jmol OpenAstexViewer
B 53 - 175 Jmol OpenAstexViewer
C 53 - 175 Jmol OpenAstexViewer
D 53 - 175 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.