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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SRP72_HUMAN (O76094)

Summary

This is the summary of UniProt entry SRP72_HUMAN (O76094).

Description: Signal recognition particle subunit SRP72
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 671 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 2 10
Pfam SRP_TPR_like 30 157
coiled_coil n/a 91 114
Pfam TPR_8 176 208
disorder n/a 209 222
disorder n/a 360 361
disorder n/a 471 472
disorder n/a 499 508
disorder n/a 513 517
disorder n/a 529 671
Pfam SRP72 531 588
low_complexity n/a 548 568
low_complexity n/a 586 603
low_complexity n/a 655 669

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O76094. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKDDVTALHC
50
51
KVVCLIQNGS FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT
100
101
IESANQQTDK LKELYGQVLY RLERYDECLA VYRDLVRNSQ DDYDEERKTN
150
151
LSAVVAAQSN WEKVVPENLG LQEGTHELCY NTACALIGQG QLNQAMKILQ
200
201
KAEDLCRRSL SEDTDGTEED PQAELAIIHG QMAYILQLQG RTEEALQLYN
250
251
QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK
300
301
KQLQAIEFNK ALLAMYTNQA EQCRKISASL QSQSPEHLLP VLIQAAQLCR
350
351
EKQHTKAIEL LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE
400
401
ELKHKPGMVS ALVTMYSHEE DIDSAIEVFT QAIQWYQNHQ PKSPAHLSLI
450
451
REAANFKLKY GRKKEAISDL QQLWKQNPKD IHTLAQLISA YSLVDPEKAK
500
501
ALSKHLPSSD SMSLKVDVEA LENSAGATYI RKKGGKVTGD SQPKEQGQGD
550
551
LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK
600
601
GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA
650
651
GAPATKKKQQ QKKKKGGKGG W                               
671
 

Show the unformatted sequence.

Checksums:
CRC64:CC0BA17AC52E3613
MD5:e85cf346747cfa24dab9bd51f2c25894

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SRP72 557 - 588 5M73 D 557 - 588 Jmol OpenAstexViewer
H 557 - 588 Jmol OpenAstexViewer
SRP_TPR_like 30 - 138 5WRW A 30 - 138 Jmol OpenAstexViewer
B 30 - 138 Jmol OpenAstexViewer
C 30 - 138 Jmol OpenAstexViewer
D 30 - 138 Jmol OpenAstexViewer
E 30 - 138 Jmol OpenAstexViewer
F 30 - 138 Jmol OpenAstexViewer
30 - 157 5M72 A 30 - 157 Jmol OpenAstexViewer
5WRV B 30 - 157 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.