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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: KCNH1_HUMAN (O95259)

Summary

This is the summary of UniProt entry KCNH1_HUMAN (O95259).

Description: Potassium voltage-gated channel subfamily H member 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 989 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PAS_9 30 135
Pfam Ion_trans 217 510
transmembrane n/a 220 239
low_complexity n/a 250 266
low_complexity n/a 346 367
transmembrane n/a 376 400
transmembrane n/a 449 466
transmembrane n/a 478 502
Pfam cNMP_binding 599 684
low_complexity n/a 713 725
disorder n/a 717 718
disorder n/a 721 729
disorder n/a 755 757
disorder n/a 764 770
disorder n/a 783 788
disorder n/a 794 828
disorder n/a 851 879
disorder n/a 885 910
disorder n/a 925 926
coiled_coil n/a 930 957
disorder n/a 938 939
disorder n/a 941 942
disorder n/a 966 989

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95259. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC
50
51
KLSGYHRAEV MQKSSTCSFM YGELTDKDTI EKVRQTFENY EMNSFEILMY
100
101
KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK
150
151
FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ
200
201
EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW
250
251
LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL
300
301
LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF
350
351
SSLKVVRLLR LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI
400
401
GDYEIFDEDT KTIRNNSWLY QLAMDIGTPY QFNGSGSGKW EGGPSKNSVY
450
451
ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA VAIMMIGSLL YATIFGNVTT
500
501
IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI VSTWSMSRGI
550
551
DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV
600
601
HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK
650
651
EATLAQSCAN VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN
700
701
LRKRIVFRKI SDVKREEEER MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA
750
751
RLAAERGGRD LDDLDVEKGN VLTEHASANH SLVKASVVTV RESPATPVSF
800
801
QAASTSGVPD HAKLQAPGSE CLGPKGGGGD CAKRKSWARF KDACGKSEDW
850
851
NKVSKAESME TLPERTKASG EATLKKTDSC DSGITKSDLR LDNVGEARSP
900
901
QDRSPILAEV KHSFYPIPEQ TLQATVLEVR HELKEDIKAL NAKMTNIEKQ
950
951
LSEILRILTS RRSSQSPQEL FEISRPQSPE SERDIFGAS            
989
 

Show the unformatted sequence.

Checksums:
CRC64:CAA8CB251300C7E5
MD5:4c4911c8ca1747c6d2a5c78941e55206

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PAS_9 30 - 133 5J7E D 30 - 133 Jmol OpenAstexViewer
F 30 - 133 Jmol OpenAstexViewer
30 - 135 5J7E A 30 - 135 Jmol OpenAstexViewer
B 30 - 135 Jmol OpenAstexViewer
C 30 - 135 Jmol OpenAstexViewer
E 30 - 135 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.