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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: FMNL1_HUMAN (O95466)

Summary

This is the summary of UniProt entry FMNL1_HUMAN (O95466).

Description: Formin-like protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1100 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 36
low_complexity n/a 3 32
Pfam Drf_GBD 27 173
disorder n/a 38 41
disorder n/a 167 194
disorder n/a 196 197
disorder n/a 199 203
Pfam Drf_GBD 202 281
low_complexity n/a 269 281
Pfam Drf_FH3 284 450
low_complexity n/a 352 363
coiled_coil n/a 394 453
disorder n/a 398 399
disorder n/a 426 431
disorder n/a 438 496
low_complexity n/a 454 472
low_complexity n/a 475 487
disorder n/a 499 638
low_complexity n/a 516 527
low_complexity n/a 524 559
low_complexity n/a 550 619
Pfam FH2 632 998
disorder n/a 641 643
disorder n/a 655 656
disorder n/a 658 697
low_complexity n/a 688 706
disorder n/a 771 772
low_complexity n/a 819 830
disorder n/a 957 958
coiled_coil n/a 990 1017
low_complexity n/a 997 1015
disorder n/a 1008 1045
low_complexity n/a 1020 1037
disorder n/a 1053 1057
disorder n/a 1088 1092

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95466. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNAAGSAEQ PAGPAAPPPK QPAPPKQPMP AAGELEERFN RALNCMNLPP
50
51
DKVQLLSQYD NEKKWELICD QERFQVKNPP AAYIQKLKSY VDTGGVSRKV
100
101
AADWMSNLGF KRRVQESTQV LRELETSLRT NHIGWVQEFL NEENRGLDVL
150
151
LEYLAFAQCS VTYDMESTDN GASNSEKNKP LEQSVEDLSK GPPSSVPKSR
200
201
HLTIKLTPAH SRKALRNSRI VSQKDDVHVC IMCLRAIMNY QSGFSLVMNH
250
251
PACVNEIALS LNNKNPRTKA LVLELLAAVC LVRGGHDIIL AAFDNFKEVC
300
301
GEQHRFEKLM EYFRNEDSNI DFMVACMQFI NIVVHSVENM NFRVFLQYEF
350
351
THLGLDLYLE RLRLTESDKL QVQIQAYLDN IFDVGALLED TETKNAVLEH
400
401
MEELQEQVAL LTERLRDAEN ESMAKIAELE KQLSQARKEL ETLRERFSES
450
451
TAMGPSRRPP EPEKAPPAAP TRPSALELKV EELEEKGLIR ILRGPGDAVS
500
501
IEILPVAVAT PSGGDAPTPG VPTGSPSPDL APAAEPAPGA APPPPPPLPG
550
551
LPSPQEAPPS APPQAPPLPG SPEPPPAPPL PGDLPPPPPP PPPPPGTDGP
600
601
VPPPPPPPPP PPGGPPDALG RRDSELGPGV KAKKPIQTKF RMPLLNWVAL
650
651
KPSQITGTVF TELNDEKVLQ ELDMSDFEEQ FKTKSQGPSL DLSALKSKAA
700
701
QKAPSKATLI EANRAKNLAI TLRKGNLGAE RICQAIEAYD LQALGLDFLE
750
751
LLMRFLPTEY ERSLITRFER EQRPMEELSE EDRFMLCFSR IPRLPERMTT
800
801
LTFLGNFPDT AQLLMPQLNA IIAASMSIKS SDKLRQILEI VLAFGNYMNS
850
851
SKRGAAYGFR LQSLDALLEM KSTDRKQTLL HYLVKVIAEK YPQLTGFHSD
900
901
LHFLDKAGSV SLDSVLADVR SLQRGLELTQ REFVRQDDCM VLKEFLRANS
950
951
PTMDKLLADS KTAQEAFESV VEYFGENPKT TSPGLFFSLF SRFIKAYKKA
1000
1001
EQEVEQWKKE AAAQEAGADT PGKGEPPAPK SPPKARRPQM DLISELKRRQ
1050
1051
QKEPLIYESD RDGAIEDIIT VIKTVPFTAR TGKRTSRLLC EASLGEEMPL
1100
1101
                                                      
1100
 

Show the unformatted sequence.

Checksums:
CRC64:91F9CE2B3B526FFC
MD5:c5303cafe19d1b7a4fb6994fb46ce11b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Drf_FH3 284 - 422 4YDH A 284 - 422 Jmol OpenAstexViewer
C 284 - 422 Jmol OpenAstexViewer
Drf_GBD 211 - 281 4YDH A 211 - 281 Jmol OpenAstexViewer
213 - 281 4YDH C 213 - 281 Jmol OpenAstexViewer
31 - 165 4YDH A 31 - 165 Jmol OpenAstexViewer
C 31 - 165 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.