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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CBX6_HUMAN (O95503)

Summary

This is the summary of UniProt entry CBX6_HUMAN (O95503).

Description: Chromobox protein homolog 6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 412 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Chromo 11 60
low_complexity n/a 15 25
disorder n/a 64 71
disorder n/a 77 79
low_complexity n/a 97 114
disorder n/a 103 104
disorder n/a 106 152
disorder n/a 154 166
disorder n/a 171 173
disorder n/a 175 178
low_complexity n/a 183 197
disorder n/a 185 217
low_complexity n/a 236 246
disorder n/a 240 370
low_complexity n/a 253 266
low_complexity n/a 271 285
low_complexity n/a 278 292
low_complexity n/a 327 354
Pfam CBX7_C 356 388
disorder n/a 381 382
disorder n/a 393 412
low_complexity n/a 393 410

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95503. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELSAVGERV FAAESIIKRR IRKGRIEYLV KWKGWAIKYS TWEPEENILD
50
51
SRLIAAFEQK ERERELYGPK KRGPKPKTFL LKARAQAEAL RISDVHFSVK
100
101
PSASASSPKL HSSAAVHRLK KDIRRCHRMS RRPLPRPDPQ GGSPGLRPPI
150
151
SPFSETVRII NRKVKPREPK RNRIILNLKV IDKGAGGGGA GQGAGALARP
200
201
KVPSRNRVIG KSKKFSESVL RTQIRHMKFG AFALYKPPPA PLVAPSPGKA
250
251
EASAPGPGLL LAAPAAPYDA RSSGSSGCPS PTPQSSDPDD TPPKLLPETV
300
301
SPSAPSWREP EVLDLSLPPE SAATSKRAPP EVTAAAGPAP PTAPEPAGAS
350
351
SEPEAGDWRP EMSPCSNVVV TDVTSNLLTV TIKEFCNPED FEKVAAGVAG
400
401
AAGGGGSIGA SK                                         
412
 

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Checksums:
CRC64:50C69233B9ADEEA3
MD5:12e88247447783a300fcf157a1ecac1c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Chromo 11 - 58 3I90 A 11 - 58 Jmol OpenAstexViewer
11 - 59 3I90 B 11 - 59 Jmol OpenAstexViewer
11 - 60 3GV6 A 11 - 60 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.