Summary
This is the summary of UniProt entry CBX6_HUMAN (O95503).
| Description: | Chromobox protein homolog 6 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 412 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam | Chromo | 11 | 60 |
| low_complexity | n/a | 15 | 25 |
| disorder | n/a | 64 | 71 |
| disorder | n/a | 77 | 79 |
| low_complexity | n/a | 97 | 114 |
| disorder | n/a | 103 | 104 |
| disorder | n/a | 106 | 152 |
| disorder | n/a | 154 | 166 |
| disorder | n/a | 171 | 173 |
| disorder | n/a | 175 | 178 |
| low_complexity | n/a | 183 | 197 |
| disorder | n/a | 185 | 217 |
| low_complexity | n/a | 236 | 246 |
| disorder | n/a | 240 | 370 |
| low_complexity | n/a | 253 | 266 |
| low_complexity | n/a | 271 | 285 |
| low_complexity | n/a | 278 | 292 |
| low_complexity | n/a | 327 | 354 |
| Pfam | CBX7_C | 356 | 388 |
| disorder | n/a | 381 | 382 |
| disorder | n/a | 393 | 412 |
| low_complexity | n/a | 393 | 410 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O95503. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MELSAVGERV FAAESIIKRR IRKGRIEYLV KWKGWAIKYS TWEPEENILD
50 51
SRLIAAFEQK ERERELYGPK KRGPKPKTFL LKARAQAEAL RISDVHFSVK
100 101
PSASASSPKL HSSAAVHRLK KDIRRCHRMS RRPLPRPDPQ GGSPGLRPPI
150 151
SPFSETVRII NRKVKPREPK RNRIILNLKV IDKGAGGGGA GQGAGALARP
200 201
KVPSRNRVIG KSKKFSESVL RTQIRHMKFG AFALYKPPPA PLVAPSPGKA
250 251
EASAPGPGLL LAAPAAPYDA RSSGSSGCPS PTPQSSDPDD TPPKLLPETV
300 301
SPSAPSWREP EVLDLSLPPE SAATSKRAPP EVTAAAGPAP PTAPEPAGAS
350 351
SEPEAGDWRP EMSPCSNVVV TDVTSNLLTV TIKEFCNPED FEKVAAGVAG
400 401
AAGGGGSIGA SK
412
Show the unformatted sequence. |
| Checksums: |
CRC64:50C69233B9ADEEA3
MD5:12e88247447783a300fcf157a1ecac1c
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Chromo | 11 - 58 | 3I90 | A | 11 - 58 | Jmol OpenAstexViewer |
| 11 - 59 | 3I90 | B | 11 - 59 | Jmol OpenAstexViewer | |
| 11 - 60 | 3GV6 | A | 11 - 60 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
