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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NET1_HUMAN (O95631)

Summary

This is the summary of UniProt entry NET1_HUMAN (O95631).

Description: Netrin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 604 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 24
low_complexity n/a 7 24
disorder n/a 38 39
disorder n/a 42 43
Pfam Laminin_N 51 283
disorder n/a 105 107
disorder n/a 188 191
disorder n/a 194 206
Pfam Laminin_EGF 285 338
Pfam Laminin_EGF 341 401
Pfam Laminin_EGF 404 451
Pfam NTR 488 594
low_complexity n/a 543 557
disorder n/a 600 601
disorder n/a 603 604

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95631. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR
50
51
CIPDFVNAAF GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK
100
101
KAHPPAFLTD LNNPHNLTCW QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ
150
151
FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ CRKMYNRPHR APITKQNEQE
200
201
AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD WVTATDIRVA
250
251
FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD
300
301
SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC
350
351
RFNMELYKLS GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA
400
401
CKACDCHPVG AAGKTCNQTT GQCPCKDGVT GITCNRCAKG YQQSRSPIAP
450
451
CIKIPVAPPT TAASSVEEPE DCDSYCKASK GKLKINMKKY CKKDYAVQIH
500
501
ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR DIACKCPKIK
550
551
PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK
600
601
CKKA                                                  
604
 

Show the unformatted sequence.

Checksums:
CRC64:9827C09D0D783B27
MD5:b89bd660826dd2a103766065953cebe9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Laminin_EGF 285 - 338 4URT A 285 - 338 Jmol OpenAstexViewer
6FKQ A 285 - 338 Jmol OpenAstexViewer
341 - 401 4URT A 341 - 401 Jmol OpenAstexViewer
6FKQ A 341 - 401 Jmol OpenAstexViewer
404 - 451 4URT A 404 - 451 Jmol OpenAstexViewer
6FKQ A 404 - 451 Jmol OpenAstexViewer
Laminin_N 51 - 283 4URT A 51 - 283 Jmol OpenAstexViewer
6FKQ A 51 - 283 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.