Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NFAC1_HUMAN (O95644)

Summary

This is the summary of UniProt entry NFAC1_HUMAN (O95644).

Description: Nuclear factor of activated T-cells, cytoplasmic 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 943 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 5 8
disorder n/a 17 46
disorder n/a 48 53
disorder n/a 56 89
disorder n/a 100 117
disorder n/a 139 153
low_complexity n/a 150 161
disorder n/a 155 159
low_complexity n/a 167 199
disorder n/a 204 218
disorder n/a 220 258
disorder n/a 262 301
low_complexity n/a 274 290
disorder n/a 312 313
disorder n/a 318 319
disorder n/a 323 371
disorder n/a 399 402
disorder n/a 413 414
Pfam RHD_DNA_bind 428 588
disorder n/a 428 451
disorder n/a 453 454
disorder n/a 503 505
disorder n/a 592 594
Pfam RHD_dimer 597 697
disorder n/a 641 644
disorder n/a 702 703
disorder n/a 705 718
disorder n/a 720 722
disorder n/a 726 731
disorder n/a 755 776
disorder n/a 782 943
low_complexity n/a 810 829
low_complexity n/a 840 852

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95644. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPSTSFPVPS KFPLGPAAAV FGRGETLGPA PRAGGTMKSA EEEHYGYASS
50
51
NVSPALPLPT AHSTLPAPCH NLQTSTPGII PPADHPSGYG AALDGGPAGY
100
101
FLSSGHTRPD GAPALESPRI EITSCLGLYH NNNQFFHDVE VEDVLPSSKR
150
151
SPSTATLSLP SLEAYRDPSC LSPASSLSSR SCNSEASSYE SNYSYPYASP
200
201
QTSPWQSPCV SPKTTDPEEG FPRGLGACTL LGSPRHSPST SPRASVTEES
250
251
WLGARSSRPA SPCNKRKYSL NGRQPPYSPH HSPTPSPHGS PRVSVTDDSW
300
301
LGNTTQYTSS AIVAAINALT TDSSLDLGDG VPVKSRKTTL EQPPSVALKV
350
351
EPVGEDLGSP PPPADFAPED YSSFQHIRKG GFCDQYLAVP QHPYQWAKPK
400
401
PLSPTSYMSP TLPALDWQLP SHSGPYELRI EVQPKSHHRA HYETEGSRGA
450
451
VKASAGGHPI VQLHGYLENE PLMLQLFIGT ADDRLLRPHA FYQVHRITGK
500
501
TVSTTSHEAI LSNTKVLEIP LLPENSMRAV IDCAGILKLR NSDIELRKGE
550
551
TDIGRKNTRV RLVFRVHVPQ PSGRTLSLQV ASNPIECSQR SAQELPLVEK
600
601
QSTDSYPVVG GKKMVLSGHN FLQDSKVIFV EKAPDGHHVW EMEAKTDRDL
650
651
CKPNSLVVEI PPFRNQRITS PVHVSFYVCN GKRKRSQYQR FTYLPANVPI
700
701
IKTEPTDDYE PAPTCGPVSQ GLSPLPRPYY SQQLAMPPDP SSCLVAGFPP
750
751
CPQRSTLMPA APGVSPKLHD LSPAAYTKGV ASPGHCHLGL PQPAGEAPAV
800
801
QDVPRPVATH PGSPGQPPPA LLPQQVSAPP SSSCPPGLEH SLCPSSPSPP
850
851
LPPATQEPTC LQPCSPACPP ATGRPQHLPS TVRRDESPTA GPRLLPEVHE
900
901
DGSPNLAPIP VTVKREPEEL DQLYLDDVNE IIRNDLSSTS THS       
943
 

Show the unformatted sequence.

Checksums:
CRC64:E72FAB10ECEB2D66
MD5:1672ed34367fadfe84e51aaf0f2548e9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RHD_DNA_bind 428 - 588 1A66 A 15 - 175 Jmol OpenAstexViewer
1NFA A 15 - 175 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.