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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AIFM1_HUMAN (O95831)

Summary

This is the summary of UniProt entry AIFM1_HUMAN (O95831).

Description: Apoptosis-inducing factor 1, mitochondrial {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 613 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
transmembrane n/a 67 85
disorder n/a 96 103
disorder n/a 110 123
low_complexity n/a 142 153
disorder n/a 270 271
Pfam Pyr_redox 302 386
disorder n/a 457 464
Pfam AIF_C 465 594
disorder n/a 512 554
low_complexity n/a 530 540
disorder n/a 603 605

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O95831. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFRCGGLAAG ALKQKLVPLV RTVCVRSPRQ RNRLPGNLFQ RWHVPLELQM
50
51
TRQMASSGAS GGKIDNSVLV LIVGLSTVGA GAYAYKTMKE DEKRYNERIS
100
101
GLGLTPEQKQ KKAALSASEG EEVPQDKAPS HVPFLLIGGG TAAFAAARSI
150
151
RARDPGARVL IVSEDPELPY MRPPLSKELW FSDDPNVTKT LRFKQWNGKE
200
201
RSIYFQPPSF YVSAQDLPHI ENGGVAVLTG KKVVQLDVRD NMVKLNDGSQ
250
251
ITYEKCLIAT GGTPRSLSAI DRAGAEVKSR TTLFRKIGDF RSLEKISREV
300
301
KSITIIGGGF LGSELACALG RKARALGTEV IQLFPEKGNM GKILPEYLSN
350
351
WTMEKVRREG VKVMPNAIVQ SVGVSSGKLL IKLKDGRKVE TDHIVAAVGL
400
401
EPNVELAKTG GLEIDSDFGG FRVNAELQAR SNIWVAGDAA CFYDIKLGRR
450
451
RVEHHDHAVV SGRLAGENMT GAAKPYWHQS MFWSDLGPDV GYEAIGLVDS
500
501
SLPTVGVFAK ATAQDNPKSA TEQSGTGIRS ESETESEASE ITIPPSTPAV
550
551
PQAPVQGEDY GKGVIFYLRD KVVVGIVLWN IFNRMPIARK IIKDGEQHED
600
601
LNEVAKLFNI HED                                        
613
 

Show the unformatted sequence.

Checksums:
CRC64:A156762BC64E6340
MD5:6cefe2ccceab6e7a5b879b77069171d4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AIF_C 465 - 594 1M6I A 465 - 594 Show 3D Structure View in InterPro
4BUR A 465 - 594 Show 3D Structure View in InterPro
B 465 - 594 Show 3D Structure View in InterPro
C 465 - 594 Show 3D Structure View in InterPro
D 465 - 594 Show 3D Structure View in InterPro
4BV6 A 465 - 594 Show 3D Structure View in InterPro
4FDC B 465 - 594 Show 3D Structure View in InterPro
4LII A 465 - 594 Show 3D Structure View in InterPro
5FMH A 465 - 594 Show 3D Structure View in InterPro
5FS6 A 465 - 594 Show 3D Structure View in InterPro
B 465 - 594 Show 3D Structure View in InterPro
5FS7 A 465 - 594 Show 3D Structure View in InterPro
B 465 - 594 Show 3D Structure View in InterPro
5FS8 A 465 - 594 Show 3D Structure View in InterPro
5FS9 A 465 - 594 Show 3D Structure View in InterPro
B 465 - 594 Show 3D Structure View in InterPro
5KVH A 465 - 594 Show 3D Structure View in InterPro
B 465 - 594 Show 3D Structure View in InterPro
5KVI A 465 - 594 Show 3D Structure View in InterPro
Pyr_redox 302 - 386 1M6I A 302 - 386 Show 3D Structure View in InterPro
4BUR A 302 - 386 Show 3D Structure View in InterPro
B 302 - 386 Show 3D Structure View in InterPro
C 302 - 386 Show 3D Structure View in InterPro
D 302 - 386 Show 3D Structure View in InterPro
4BV6 A 302 - 386 Show 3D Structure View in InterPro
4FDC B 302 - 386 Show 3D Structure View in InterPro
4LII A 302 - 386 Show 3D Structure View in InterPro
5FMH A 302 - 386 Show 3D Structure View in InterPro
5FS6 A 302 - 386 Show 3D Structure View in InterPro
B 302 - 386 Show 3D Structure View in InterPro
5FS7 A 302 - 386 Show 3D Structure View in InterPro
B 302 - 386 Show 3D Structure View in InterPro
5FS8 A 302 - 386 Show 3D Structure View in InterPro
5FS9 A 302 - 386 Show 3D Structure View in InterPro
B 302 - 386 Show 3D Structure View in InterPro
5KVH A 302 - 386 Show 3D Structure View in InterPro
B 302 - 386 Show 3D Structure View in InterPro
5KVI A 302 - 386 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;